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Your Good Health: Man takes niacin for cholesterol, gets diabetes

Niacin belongs to the B family of vitamins and is also known as nicotinic acid or vitamin B-3. Despite such health benefits, niacin impairs fasting blood glucose. The goal of this study was to determine the effect of niacin administration on serum total- and phosphorylated fetuin-A (phosphofetuin-A) concentrations in individuals with MetS and correlate with changes in serum lipids, insulin sensitivity, and markers of inflammation. Total FFA concentrations were lower during niacin infusion in both lean (50 ± 4 vs. We had totally different experiences, but the same outcomes. After a friend told me that niacin would lower my high cholesterol, I began taking approximately 1,000-1,200 mg daily in my early 60s. Although few people in the industrialized world are actually deficient in niacin, many may benefit from additional amounts in supplement form to help treat assorted complaints.

The findings suggest that niacin exerts beneficial effect on adiposity, glucose tolerance and insulin sensitivity, and plasma lipids, and that it specifically modulates the level of serum adiponectin under obese condition. The niacinamide form does not cause flushing, but will not reduce cholesterol levels. Mitigating this residual risk is clearly one of the biggest challenges in preventive cardiology. I have never been a big fan of Niacin because it causes pretty bad flushing, increases uric acid/gout, and most importantly raises blood glucose. The LDL level should be less than 130 mg/dl and the HDL level should be greater than 35 mg/dl. It is also often more affordable than statin drugs like Lipitor®. I am now 73 years old and prediabetic.

Although my brother and I no longer have to take diabetic medications, we still struggle with blood sugar levels that are higher than they should be. It may also cause mental problems, nervousness, depression, loss of appetite, redness of the tongue, gum ulcers, diarrhea and other auto-immune related problems. 2). It is a very common side- effect that niacin, in the doses necessary to change blood cholesterol, can affect the liver, seen by elevated liver enzymes in the blood. The increase in blood sugar is not as well known, but it is common, and usually of small magnitude. However, in a person who is at risk for Type 2 diabetes due to it running in the family (genetic risk), the niacin can be enough to make a predisposition become overt. The initial results in December 2012 led Merck to stop pursuing approval of Tredaptive in the U.S.

This occurs in approximately one person for every thousand people taking statins for a year. However, in that same group, we would expect five people to have a heart attack or death prevented by taking the statin, so there is clearly more benefit than harm, if the people taking statins are of appropriate risk to do so.

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