Hi all, Can any one give any advice on my post, I have been diagnosed in February with type 2, over the period of time up to now I have changed my diet and exercise regularly. Reporting in the September issue of the Journal of Clinical Endocrinology and Metabolism, researchers from the David Geffen School of Medicine at UCLA suggest there is a correlation between greater muscle mass, relative to body size, and a substantially decreased risk of developing the metabolic changes that lead to diabetes. This review provides an overview and critical evaluation of the effects of weight loss and exercise interventions on skeletal muscle mitochondria, along with implications for insulin resistance, obesity, type 2 diabetes and aging. Dr. Associate Professor Ravi Kambadur and his team from the NTU School of Biological Sciences found that a protein called myostatin, which controls muscle cell growth, is responsible for initiating muscle loss. Apoptosis in enteric neurons under hyperglycemia in vitro was determined by cleaved caspase-3 Western blotting and protective effects of lipoic acid were evaluated. Additionally, functional performance was decreased in the men with type 2 diabetes, with longer sit-to-stand time and lower handgrip strength.
“For example, about 30 per cent of cancer patients die not because of cancer, but because of muscle loss also known as cachexia,” said Prof Kambadur. The starting point is .8 grams of protein per Kg of body weight. In a previous study, she and her colleagues had shown that protein metabolism was accelerated in men with diabetes on a 17% protein diet. adults will have the condition by 2050. Muscle tissue is a very plastic tissue, meaning that the size, shape and metabolic characteristics are highly changeable. Studies have also found that older people have more myostatin and this can explain why when one ages, muscles become weaker. This decline of HGH is part of what drives your aging process, so maintaining your HGH levels gets increasingly important with age.
Imaging combined with specific labelling techniques will allow real-time monitoring of organelle dynamics. Simply stated, developing and maintaining healthy muscle tissue is one of your best defenses against most chronic disease. Frequently exercised (and adequately stretched) muscle tissue gets incredibly hungry for fuel, and it is this very process of depletion-and-fueling that creates metabolically active muscle tissue. Let’s see how this works. Exercise increases mitochondrial content in muscle tissue Mitochondria are the tiny energy factories present in practically all cells in tissues across the body, and are highly prevalent in muscle tissue. You mention your body not making enough insulin, and therefore it cannibalising your muscle sources. Frequent exercise stimulates the mitochondrial compartment within the cell to grow, in order to generate MORE energy during the next exercise bout.
Exercise depletes muscle tissue of it’s two stored fuels: glucose and fatty acids Glucose is stored in the muscle tissue in the form of glycogen, and fatty acids are stored as triglyceride (tri-glis-er-ride). Both fuels are stored “on board” in the muscle tissue because it allows contracting muscle fibers to utilize these fuels for energy during exercise without having to depend on other tissues to deliver them. An Analogy: Think of Muscle Tissue as a Car with Two Fuel Tanks Imagine you drive a 21st century car that has two fuel tanks. One tank contains orange juice, and can hold 15 gallons. The second tank contains coffee (caffeinated), and can hold 2 gallons. Orange Juice: The OJ is clearly the more plentiful of the two fuels, and is able to power your car for hundreds of miles. Your car is tuned to operate on this fuel for long distances, and does so by “sipping” OJ efficiently.
Coffee: Coffee in the second tank has a very specific purpose: to provide FAST acceleration. Every time you accelerate out of a stop light, coffee is selected as the fuel of choice on the fly, and provides a quick high-power boost for a short period of time. Once a constant speed is attained, the car automatically switches back to OJ. Note that because coffee is used for short periods of time simply to accelerate the car in times of need, the size of this tank can be quite small. BDNF also triggers numerous other chemicals that promote neural health. However, diseases with overlapping network modules, such as obesity-related sarcopenia and type 2 diabetes, can be expected to benefit from ‘interactome’-based platforms, predicting common molecular pathways despite incomplete multiomics data. This is your muscle’s “caffeinated beverage.” In lower intensity situations (long distance or constant speed movements such as running/biking/swimming/hiking etc), fatty acids are preferentially oxidized for energy because they can provide sustained energy for long periods of time.
This is your muscle’s version of OJ.