Simultaneous control of blood glucose and other risk factors such as hypertension and dyslipidaemia is essential for reducing the risk of complications associated with type 2 diabetes mellitus (T2DM). Limitations of use: not for the treatment of type 1 diabetes or diabetic ketoacidosis. Interventions directed at glucose and lipid level control in T2DM patients may reduce micro- and macrovascular disease. When used along with changes to diet and exercise, this medication helps to reduce cholesterol levels in the blood. Materials and Methods: A Medline search was conducted to provide evidence to support the efficacy and safety for the use of colesevelam tablets or oral suspension preparations when treating patients with lipidemia, T2DM, or both. Priority was placed on data obtained from human randomized controlled trials. Although the results show that colesevelam reduced HbA1c, the results should be interpreted with caution due to the small sample size, heterogeneity and risk of bias in the individual studies.
Administer phenytoin, cyclosporine, oral vitamin supplementation, drugs known to have reduced GI absorption when given concomitantly, or drugs that have not been tested for interaction (especially those with narrow therapeutic index) at least 4 hrs prior to colesevelam. Concomitant use with warfarin decreases INR; monitor INR. It is different from most other cholesterol-lowering drugs on the market because it is non-systemic, meaning that the body does not absorb it and it is eliminated without traveling to the liver or kidneys. Consequently, compensatory effects lead to increased LDL clearance from blood, resulting in decreased serum LDL levels. Mechanism unknown in the treatment of DM. Like Metformin, they also decrease the amount of glucose released from the liver. Do not take the powder without mixing it in liquid.
Monitor INR prior to initiation in patients on warfarin therapy. Monitor for hypertriglyceridemia-induced pancreatitis, hypoglycemia, dysphagia, esophageal obstruction, and other adverse events. Periodically monitor lipid profile (eg, TGs, non-HDL), blood glucose, and coadministered drug levels. It’s also possible to use all sorts of different fitness apps to monitor and track your progress, and many of them are free to use. Postgrad Med 2009;121:25-30. Globalement, le risque de biais de ces essais était peu clair ou élevé. Advise to consume diet that promotes bowel regularity.
Similarly, the initiation of a pharmacological agent for treatment of hypercholesterolaemia was based on the recommendations of the American Diabetes Association, American Heart Association and the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III). Instruct patients with primary hyperlipidemia to adhere to the recommended diet of the National Cholesterol Education Program. Instruct patients with type 2 DM to adhere to dietary instructions, regular exercise program, and regular testing of blood glucose. Advise to notify physician if dysphagia or swallowing disorders occur. This product includes phenylalanine.