The objective of this study is to assess and quantify the risk for gestational diabetes mellitus (GDM) according to prepregnancy maternal body mass index (BMI). This may be the case for many Asian-Americans who look slim, but actually face a higher risk of diabetes than people belonging to other ethnic groups. Weight, height, and recreational activities were reported at study entry. 10,568 patients were followed for a median of 10.6 years (interquartile range, 7.8 to 13.4). Similarly, the accumulation of macrophage-derived foam cells[11, 12] and T helper type 1 (Th1) cells within atherosclerotic plaques, and the resultant chronic inflammation of the arterial wall, plays a key role in plaque progression. (8) concluded that increasing BMI is associated with younger age at diagnosis only in subjects with a reduced β-cell function and hypothesized that obesity is accelerating the onset of type 1 diabetes at a higher stage in the natural history of the disease, after substantial autoimmune destruction of the β-cell has occurred. After 9 years of follow-up, we recorded the frequency of new cases of diabetes, according to their BMI at inclusion.
11.6 life years for men), age, and ethnicity. If participants had a one-year age increase, one-point BMI increase, one additional year of diabetes duration or reported “less than excellent” general health, their odds of doing no physical activity were raised. We used 80 years as our upper age cut point because aging is associated with changes in insulin metabolism (21), and after this age, fasting insulin is not a well-studied risk factor (22,23). 24.4), according to the results.