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Type 2 diabetes risk varies with magnesium intake, genes and ethnicity

If you’ve been following along in health news lately, you’ll know that inflammation has been named as one of the most likely culprits in a whole host of chronic diseases, from rheumatoid arthritis to cancer to cardiovascular problems. Ka He of the University of North Carolina at Chapel Hill and colleagues found. Fasting serum magnesium level, categorized into 6 levels, and dietary magnesium intake, categorized into quartiles, were measured at the baseline examination. For now, we’re going to focus on heart health and magnesium’s role in those affected by diabetes. Certainly, diabetics who are currently on any of these medications are at increased risk for magnesium deficiency. There was a positive correlation between urinary glucose and magnesium excretion. There was no difference for these two changes among T2D with and without complications; In addition, there was a significantly positive correlation of serum Mg levels with serum Ca levels only in T2D patients, and also a significantly positive correlation of urinary Mg levels with urinary Ca levels in control, IGT patients, and T2D patients.

Women Health 1992;19:117-31. With this resource they were able to analyze the magnesium intake, type 2 diabetes status, and genes of 7,287 black women and 3,285 Hispanic women between the ages of 50 and 79. Magnesium may help alleviate or prevent one of the most painful and debilitating conditions that can afflict adults—migraine headaches. In all, the team looked at 17 genes and in particular at 583 common one-letter differences in their genetic code (e.g., what would normally be an A is instead a G). These differences are called single-nucleotide polymorphisms — SNPs. For example, lead author by Kei Hang Katie Chan and her co-authors found that among Hispanic American women with high magnesium intake, those with the SNP “rs8028189” on the gene “NIPA2” had a 35-percent lower type 2 diabetes risk than women overall, an uncommonly high advantage. Black women, meanwhile, showed a 16-percent lower risk for each copy of the gene “CNNM1” they carried with the SNP “rs6584273.” Here, however, there was no clear dependence on how much magnesium they consumed.

Liu’s team recently became one of the first to win a grant under the American Heart Association’s Cardiovascular Genome-Phenome initiative. He will use that support to pursue further studies into the links among diet, genetics, ethnicity, and the risks of diabetes and cardiovascular disease. These foods include green leafy vegetables, beans, a variety of nuts, seeds, grains, and a few surprises: blackstrap molasses, seaweed, and chocolate. Disclaimer: AAAS and EurekAlert! Cells need roughly 14 times the amount of potassium inside of cells than sodium. However, not all studies supported this.

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