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Type 2 Diabetes: Jardiance® (empagliflozin) as an add-on therapy significantly reduced blood glucose and body

Osaka, Japan, January 17, 2007 — Takeda Pharmaceutical Company Limited (“Takeda”) today announced that on January 8, 2007, Takeda Global Research & Development Centre (Europe), Ltd. Patients with type 2 diabetes mellitus are often treated using oral anti-diabetic drugs. Glimepiride/pioglitazone should not be used to treat patients who have heart failure with symptoms, or who have moderate to severe heart failure. These differences increase over time but are noticeable even after the first 10 years of follow-up. Kontrol diabetes yang sesuai juga dapat mengurangi risiko serangan jantung atau stroke. Antibodies to GAD65 were detected using radioimmunoassay (Oslo University Hospital in-house assay using translation-labeled GAD); an antibody index of ≥0.05 was considered positive and provided a sensitivity of 82% and specificity of 99% (Diabetes Autoantibody Standardization Program 2010). Significantly fewer confirmed hypoglycaemic events were reported for empagliflozin compared with glimepiride (2.5 percent vs.

CANA 100 and 300 mg reduced body weight by 3.7 and 4.0 kg, respectively compared to a 0.7 kg increase with glimepiride. Lipolysis was evaluated by measurements of nonesterified fatty acid (NEFA) and glycerol concentration and measurement of glycerol production. in patients with type 2 diabetes and inadequate glycaemic control on metformin monotherapy, the addition of sitagliptin or glimepiride led to similar improvement in glycaemic control after 30 weeks. If at any time during the study the glycemic control became unsatisfactory, treatment was given by the physician at his discretion and the subject was excluded at this point from the study. If you have trouble eating solid foods, use sugar-sweetened drinks as a carbohydrate substitute or eat small amounts of bland food. Thus far, only limited evidence regarding the comparative effects of these drugs in the elderly has been synthesized and recent concerns regarding the cardiovascular effects of these drugs have been noted. Viral hepatitis serology was performed and was negative for hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV).

In conclusion, glimepiride was efficacious and safe in type 2 diabetes Thai patients and 1-2 mg of glimepiride appeared to be a sufficient dose for most newly diagnosed type 2 diabetic patients. Patients in the empagliflozin 10 mg and 25 mg groups were taking mean total daily insulin doses that were 8.8 IU/day and 11.2 IU/day lower, respectively, than the dose patients in the placebo group were taking. More patients with initial HbA1c levels greater than or equal to 7 percent and treated with empagliflozin, achieved HbA1c levels below 7 percent (31 percent, 42 percent and 21 percent of patients in the empagliflozin 10 mg, 25 mg and placebo groups, respectively). Dose in patients with well controlled diabetes: the usual dose range in patients with well controlled diabetes is 1 to 4 mg daily. About Empagliflozin Empagliflozin, marketed in Europe as Jardiance® is an oral, once daily tablet for the treatment of adults with Type 2 Diabetes and is part of the SGLT2 inhibitor class. If you think that you or anyone else may have taken too much of this medicine, immediately telephone your doctor or the Poisons Information Centre (Tel: 13 11 26 in Australia) for advice. Unlike most classes of existing oral T2D treatments, SGLT2 inhibitors like empagliflozin work independently of β-cell function and insulin pathway.

Boehringer Ingelheim and Eli Lilly and Company In January 2011, Boehringer Ingelheim and Eli Lilly and Company entered into an alliance in diabetes that centres on compounds representing several of the largest diabetes treatment classes. Models are imperfect instruments of real world outcomes. By joining forces, the companies demonstrate commitment in the care of patients with diabetes and stand together to focus on patient needs. 2013. About Boehringer Ingelheim The Boehringer Ingelheim group is one of the world’s 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, Boehringer Ingelheim operates globally with 142 affiliates and a total of more than 47,400 employees. The focus of the family-owned company, founded in 1885, is researching, developing, manufacturing and marketing new medications of high therapeutic value for human and veterinary medicine.

Prandial glucose AUC0–2 h was similarly reduced in both groups (−1.7 mmol · h−1 · l−1 for vildagliptin vs. Today we are building upon this heritage by working to meet the diverse needs of people with diabetes and those who care for them. eGFR remained stable throughout the 52 weeks in both groups (Fig. For more information, visit www.lillydiabetes.com. About Eli Lilly and Company Lilly is a global healthcare leader that unites caring with discovery to make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism.

To learn more about Lilly, please visit us at www.lilly.com and http://newsroom.lilly.com/social-channels. This press release contains forward-looking statements about empagliflozin for the treatment of type 2 diabetes. It reflects Lilly’s current beliefs; however, as with any such undertaking, there are substantial risks and uncertainties in the process of drug development and commercialization. There is no guarantee that future study results and patient experience will be consistent with study findings to date or that empagliflozin will prove to be commercially successful. For further discussion of these and other risks and uncertainties, please see Lilly’s latest Forms 10-Q and 10-K filed with the U.S. Securities and Exchange Commission. Lilly undertakes no duty to update forward-looking statements.

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