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Type 2 Diabetes Comorbidities and Treatment Challenges: Rationale for DPP-4 Inhibitors: Postgraduate Medicine: Vol 122,


Dr. This study was conducted in one rural county and two urban districts in two geographical locations of Beijing and Shanghai, which might account for the lack of an observed statistical difference because of the predominance of an urban population. We tested the hypothesis that small muscle mass exercise tolerance is reduced in persons with T2D versus Controls (matched for age, body mass index, fitness, comorbidities, non-T2D medications) and that this is related to blunted MBF. The NCM will contact the PCPs in order to de-pseudonymize ‘her’ patients and to deliver the assessment. The study protocol was approved by the Institutional Ethical Committee. The primary outcome will be the differences between the intervention and control groups in changes of diabetes-related self-care behaviours from baseline to T1 using a German version of the revised Summary of Diabetes Self-Care Activities (SDSCA-G). Mean adjusted total costs were $16,435; $4558; $445; $5675; and $8765 for CAD, CVD, hypoglycemia, complication, and renal failure episodes, respectively.

CONCLUSIONS: Most medical costs incurred by patients with type 2 diabetes are related to complications and comorbidities. We believe that there are two main explanations for our finding that depression was more common in patients with multiple vascular co-morbidities. The following will focus on comorbidities of obesity that affect the endocrine system, with the goal of providing guidance for initial evaluation and when referral to an endocrinologist is warranted. Dipeptidyl peptidase-4 inhibitors offer efficacy similar to other drug classes, and are well tolerated with a lower risk of hypoglycemia, weight-neutral effects, and a low propensity for drug-drug interactions. We found that a higher number of comorbidities did not further decrease mental health, role limitations due to emotional problems and mental component score. ©2012 American Medical Association.

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