[ Diabetes Type 2 ]

The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular


Interleukin (IL)-13 is a cytokine primarily produced by the T-helper (Th)-2 subset of lymphocytes that possesses powerful anti-inflammatory properties. Several genes have been associated with susceptibility and/or protection for T1DM (2, 3, 4, 5, 6, 7), but the disease risk is mostly influenced by genes located in the class II region of the major histocompatibility complex [human leukocyte antigen (HLA)]. The islet cell-reactive T cell clones inhibit adoptive transfer of insulin-dependent diabetes mellitus and intraislet lymphocytic infiltration. Treatment consists in daily administration of exogenous insulin under self-monitoring conditions of blood glucose and diet; new non-invasive insulin products are now available. La cause de la rupture de la tolérance du soi, responsable des phénomènes d’auto-immunité, reste inconnue bien que ses origines génétiques en liaison avec des gènes de la région de la classe II MHC aient été bien décrites. Th17 cells exhibit significant plasticity and converted to Th1-like cells under pathogenic conditions. While total T cells and CD4(+) T cells expressing high levels of CD25 (CD4(+) CD25(hi) ) were unchanged, the frequency and total numbers of CD4(+) T cells expressing an intermediate level of CD25 (CD4(+) CD25(int) ) were decreased in LADA patients.

Serum insulin and hsCRP levels were determined with radioimmune and immunoturbidimetric assays, respectively.

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