One in every five older people living in UK care homes has dehydration, suggesting that they are not drinking enough to keep themselves healthy. It is associated with slowly progressive end-organ damage in the eyes and kidneys, but also in the brain. The steps from diabetes to vascular dementia are easy to follow since diabetes damages blood vessels, increasing the risk of heart disease, strokes and vascular diseases as we age. However, none of these studies used imaging techniques to evaluate atherosclerosis or evidence of cerebrovascular disease, such as infarctions. The POEM email is usually a descriptive headline with a brief paragraph of information summarizing a recent journal article for the busy, practicing physician. In fact, dementia affects almost one-fourth of all people with diabetes who are 75 years old or older. Of demented subjects, 37 subjects had AD, 30 subjects had VD.
Cerebrovascular disease may exacerbate AD through direct interactions between the two pathological processes or through cognitive impairment secondary to cerebrovascular disease “unmasking” AD at an earlier stage than it would otherwise become apparent. In the unadjusted model, those with DM had lower odds of AD (odds ratio [OR] 0.73; 95% confidence interval [CI] 0.72-0.74) and VaD (OR 0.91, 95% CI 0.89-0.92). Novo Nordisk, the Danish company that developed the drug, is also providing support. Inclusion of interaction terms (age, race/ethnicity, depression, stroke, and hypertension) made the relationship between diabetes and VaD not significant (OR 1.002, 95% CI 0.97-1.03), but the relationship of DM with AD remained significant (OR 0.57, 95% CI 0.56-0.58; P < .05). Wray, Linda A. The screening also involved a detail of the socio-demographic profile of study population. Further exploration of the relationship between DM and AD is warranted.