[ Diabetes Type 2 ]

[Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]. – PubMed

Lactic acidosis is a serious medical condition in which too much lactate builds up in the body, resulting in an excessively low pH. The aim of this study was to identify causes of lactic acidosis in this group of patients and to measure the extent of metabolic disturbances based on the available laboratory test results. Food and Drug Administration, Rockville, Maryland. Lactic Acidosis and Exercise: What You Need to Know – WebMD Lactic acidosis occurs when lactic acid accumulates in the bloodstream. The United Kingdom Prospective Diabetes Study demonstrated impressive reductions in diabetes-related endpoints and mortality in overweight patients with type 2 diabetes who used this drug [3]. Patients with normolactatemia and hyperlactatemia were similar in terms of metformin dosage and laboratory parameters. The biochemical indexes included creatinine (Cr) and hepatase were measured with enzymatic procedures.

Correlation studies showed a positive correlation between serum creatinine and plasma metformin and between plasma metformin and arterial lactate but, for the latter correlation, only in patients with metformin accumulation. When oxygen levels decrease at the muscle, then energy production must switch from “aerobic” (with oxygen) to “anaerobic” (without oxygen) metabolism and therefore lactic acid levels rise. After 8 hours of hemodialysis the acid-base metabolism was almost balanced and the vigilance of the patient normalized. No further

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[ Nutrition ]

Scottish Medicines Consortium Briefing Note: dapagliflozin (Forxiga)

Purpose: The purpose of this review article is to provide guidance to health care providers regarding the use of dapagliflozin–metformin XR (extended release) as a therapeutic option for the treatment of patients with type 2 diabetes mellitus (T2DM). Dapagliflozine is een nieuw medicijn waarmee diabetes  kan worden behandeld. Risk to pregnant or lactating women: dapagliflozin is not for use in pregnant or lactating women because of increased risk of malformations and irreversible damage (pregnancy category D). De standaarddosering is 1x daags 10mg. The safety assessment should include all undesirable changes of medical findings (including a clinical test finding) noted during medical visits as needed according to local practice guidelines and all AEs associated with surveillance drug administration. In January 2014 the second drug in this class was approved: dapagliflozin or Farxiga. Forxiga, the first medicine in the SGLT2 class to gain regulatory approval, is currently approved for the treatment of type 2 diabetes in the European Union, Argentina, Australia, Brazil, Mexico and New Zealand.

Neither study personnel nor subjects will know what treatment is given. The results of three studies showed that dapagliflozin when added to metformin was as good as a sulphonylurea in combination with metformin, and better than placebo (a dummy medicine containing no active treatment) in terms of glycaemic control, as measured by change in HbA1c. Once NICE issues its guidance

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[ Diabetes Type 2 ]

Becoallergy (cetirizine)

What is it used for? Millions of people deal with the itchy, watery eyes and stuffy noses caused by seasonal allergies every day. Web pages that are archived on the Web are not subject to the Government of Canada Web Standards. Because this drug may cause drowsiness, users should be careful when driving or attempting dangerous activities. End User acknowledges and agrees that its sole and exclusive remedy in the event of such delay is to not accept these terms and conditions. Depending on the brand and the form of diphenhydramine skin product you are using, the package information may state that its use is not recommended in children younger than 2, 6, or 12 years unless directed by the doctor. One type is a phototoxic reaction, which occurs when UV radiation reacts with a drug to form compounds that damage the skin.

Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. It is stored in cells called mast cells, in almost all tissues of the body. Ask your doctor or pharmacist for more details about using your product safely. Often decongestants are combined with other drugs (especially antihistamines) in OTC medications. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. If you are taking Benadryl Allergy Ultratabs without a prescription, follow any warnings and precautions on the label. Disclaimer: Every effort has been made to ensure that

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[ Diabetes Type 1 ]

Lilly’s Experimental Diabetes Drug Helps Reduce Weight

The diabetes medication Januvia, manufactured by pharmaceutical giant Merck, is being blamed for another patient’s death. This legally prescribed time limit is referred to as a “statute of limitations,” and prevents a claim from being filed after the designated time has elapsed. Diabetes has become a worldwide scourge, and use of incretin drugs – alone or in combination with other diabetes medications – is on the rise. In type 2 diabetes, the body does not produce enough insulin or the cells ignore the insulin. Januvia and its combination version Janumet are classified as DPP-4 inhibitors. Glenmark, on the other hand, had contended that it has used ‘Sitagliptin Phosphate’ in its anti-diabetes drugs, Zita and Zita-Met, and US firm has no patent right over this salt. Like that drug, ITCA 650 is a GLP-1 agonist, designed to promote the body’s natural production of insulin.

The Kenilworth, New Jersey-based drugmaker’s revenue increased 0.6 percent to $9.84 billion, compared with the $9.79 billion predicted by analysts. How To Take Take Generic Januvia orally, with or without food. In August of this year, a study was released which showed that Jardiance – a diabetes drug developed by Eli Lilly & Co. Other regulatory agencies have also reviewed the evidence regarding the pancreatic safety of incretin-based therapies and concluded that a causal association could not be established. Byetta, introduced in June 2005, has stirred especially

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