June 2, 2015. We searched MEDLINE and EMBASE from inception through 1 October 2008. “We believe this study has several implications,” said lead author David Margel, MD, PhD, a uro-oncologist at Rabin Medical Center in Petah Tikva, Israel, who conducted the research while at the University of Toronto. Surgery, radiation and radioactive seed implants can cause disorders such as erectile dysfunction and urinary incontinence. Obese diabetic men (BMI > 30 kg/m(2)) showed a reduced risk (OR, 0.72; 95% CI, 0.65-0.80) compared with men without diabetes. Among these diabetic men without metformin use, PCa incidence was higher in Hispanics and AA than in non-Hispanic White (NHW). They also had significantly more comorbid conditions (other than DM) and a greater BMI at baseline.
Specifically, diabetes was associated with decreased risk of high-grade PCa in normal-weight men but increased risk in obese men (OR 0.35 vs 1.38). However, in contrast to the metabolic syndrome, androgen deprivation therapy increases subcutaneous fat and high density lipoprotein cholesterol. Overall, one of four studies found increased prostate cancer mortality, one of two studies found increased nonprostate cancer mortality and one study found increased 30-day mortality. Diabetes status was available for all 8122 men in the REDUCE efficacy population. As yet, few studies have explored a relationship between type 1 diabetes mellitus and cancer 3. No association of ever use with other cancers was observed