Fasting plasma glucose concentrations (FPG) predict development of type 2 diabetes. Glucose tolerance is adversely affected by the chemical structure of the progestins contained in oral contraceptives such as estrane (norethindrone, ethynodiol) and particularly gonane (norgestrel). These factors can be measured in the intact organism with physiologically based minimal models of glucose utilization and insulin kinetics. The response rate was 71% for men and 80% for women. Known cases included 26 patients with NIDDM and 1 with IGT. We describe our experience of applying the ADA criteria and propose a clinical assessment tool to refine the selection of children for screening by the oral glucose tolerance test (OGTT). Control groups (C) received vehicle.
Our findings indicate that PCOS patients with GI represent a subgroup with specific clinical and hormonal characteristics. Accordingly, screening for diabetes is recommended for these women. However, the use of RBS alone is not sufficient to exclude poor metabolic control. Thus, prevention of offspring type 2 diabetes may require strategies that focus on improving gestational glucose tolerance even within the normal range. These may be useful for developing potential preventive strategies. This definition does not exclude glucose intolerance that may have antedated pregnancy (1). Gestational diabetes generally has few symptoms and it is most commonly diagnosed by screening during pregnancy.
There were significant