Sulfotransferase (SULT) function has been well studied in healthy human subjects by quantifying mRNA and protein expression and determining enzyme activity with probe substrates. Twenty seven individuals (16M/11F) participated in two separate randomized single-blind, 2 day protocols. DHEA has its own hormone effects. We used the random-effects model to pool across studies and evaluated heterogeneity using the I(2) statistic. Take this medicine by mouth with a glass of water. Thirteen men and 17 women between 40 and 70 years of age took 50 milligrams of DHEA per day for six months. Scientists noted that DHEA had prevented oxidative stress in other studies and wanted to test its effect in diabetes.
This suggests that DHEA may act in insulin-resistant mutant mice and in aging normal mice to increase the sensitivity to insulin. DHEA also appeared to counteract bone loss caused by medication and increase bone density. DHEA may interact with agents for Alzheimer’s and arthritis; agents for the brain, heart, skin or urinary tract; agents that improve mental function; agents that may affect blood vessel width; agents that may affect GABA; agents that may affect the immune system; agents that may be toxic to the liver; agents that may lower seizure threshold; alcohol; androgens; angiotensin-converting enzyme (ACE) inhibitors; anticancer agents; antidepressants; antiestrogens; anti-inflammatories; antiobesity agents; antipsychotic agents; antiseptics; antiviral agents