Although mortality of diabetic ketoacidosis (KA) has decreased during the past 20yr to 1–2%, hyperosmolar non-ketotic coma (HNC) is still lethal in 20–30% of cases due to severe underlying conditions or to complications. Plasma osmolality (Posm) was 342.2 +/- 11.4 mOsm/kg H2O, and hematocrit, serum protein, and blood urea nitrogen were also elevated at hospitalization. Carlos Mercado lapsed into a diabetic coma on Aug. The breakdown products (called ketones) of these fuel sources saturate the blood, and can cause permanent damage and death. A substantial part of the brain’s energy source is derived from ketones, which in themselves can depress sensorium. Glucose is a form of sugar that serves as the body’s primary fuel. An abnormal electrocardiogram, occular convergence and chorea like movement disappeared after correction of metabolic disturbances.
When blood glucose concentrations decrease below 14 mmol/l, blood glucose concentrations should initially be maintained at this level because rapid lowering below this level may increase the risk of brain oedema. These results indicate that both non-osmotic and osmotic stimuli are involved in the mechanism for AVP release in patients with diabetic coma, and that the non-osmotic control of AVP may contribute to circulating homeostasis, protecting against severe blood volume depletion in diabetic patients suffering from hyperglycemia and dehydration. Corizon is also facing a lawsuit over the death of 19-year-old