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Drinking alcohol and poor nutrition also have the same effect. In the same intervention study we found that higher body fat accumulation was significantly associated with higher SCD-1 isoform expression in control women, who had 25% more body fat mass than men . Therefore, our results suggest that FM has anti-diabetic effect as a functional food to treat type II diabetes mellitus. Besides, it was shown that depletion of PPARγ in adipose tissue causes insulin resistance, since decreased PPARγ action in mature adipocytes, leads to reduced expression of key genes required for insulin signaling in adipocytes . It was previously shown that