This study aimed to estimate the current cumulative risk of end-stage renal disease (ESRD) due to diabetic nephropathy in a large, nationwide, population-based prospective type 1 diabetes cohort and specifically study the effects of sex and age at onset. Pour vérifier l’influence du diabète prépubertaire, nous avons comparé les corrélations entre la prévalence de la rétinopathie et la durée du diabète chez des patients ayant développé un diabète de type 1 avant et après la puberté. A total of 436 children (204 boys, 232 girls, mean age at diagnosis of diabetes 8.2+/-0.2 years) were followed at our outpatient diabetes centre. Blood pressure was measured at enrollment. Methods. RESULTS Within the first 5 years from diagnosis, 19.4% of individuals (median age 13 years) had neither GADA nor IA-2A, and by 6 to 13 years after diagnosis (median age 18 years), 31.7% were antibody-negative. Results Differential effects on risk of type 1 diabetes of Sardinian heritage and social class in the age groups 0–14 and 15–29 years were found.
There was a trend that the frequencies of DR9 decreased with the increase of age at onset, but there was no significant difference of DR3, DR4, DR9, DR3/4, DR3/9 and DR4/9 frequencies between diabetes children with age onset 0-10 years and 11-17 years. Cardiac events were defined by history of angina, myocardial infarction, heart failure and/or coronary revascularization. Time since diabetes onset influenced age at onset of puberty