[ Diabetes Type 2 ]

Sex differences in the association between serum ferritin and fasting glucose in type 2 diabetes


RESEARCH DESIGN AND METHODS—We genotyped the +49G>A and CT60G>A variants of the CTLA4 gene in fulminant type 1 diabetic patients (n = 55), classic type 1A diabetic patients (n = 91), and healthy control subjects (n = 369). Multi-factorial courses combining genetic disposition and environmental factors might be in play, and through the years, there has been a mounting interest in the innate immune system’s role in the development of T1D. Previous results were contradictory, which may be explained by differences between men and women in responsiveness of the vasopressin system. The “moving wall” represents the time period between the last issue available in JSTOR and the most recently published issue of a journal. These differences reflected the allele frequencies in newborn cohorts in which HLA-DQB1*02 and DQB1*0301 were found more often in Turku and DQB1*0302 more often in Oulu (P < 0.0001 for all differences). All other ethnic groups had significantly (p58 mmol/mol, 7.5%) compared to the White Scottish group, despite generally younger mean age and lower BMI. Serum ferritin concentration was positively associated with type 2 diabetes among women in all ethnic groups (odds ratio [OR] ethnic Dutch: 1.07 [95% CI 1.01-1.13]; OR South Asian Surinamese: 1.05 [1.00-1.10]; OR African Surinamese: 1.05 [1.01-1.10]), but not among men. Although type 2 diabetes is much more common than type 1, the causes for it aren’t fully understood. 8 in the journal Nature Genetics — is the first result from the Metformin Genetics Consortium, an international collaboration led by Kathy Giacomini, PhD., a professor of bioengineering and therapeutic sciences in UC San Francisco’s schools of Pharmacy and Medicine and Ewan Pearson, PhD, professor of diabetic medicine at the University of Dundee in Scotland. Absorbed: Journals that are combined with another title. Further evaluation of the variation in sex differences between ethnic groups is warranted, particularly among the African Surinamese, to understand the mechanisms behind these sex differences.

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