N2 – Aims/hypothesis: No studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. / Das-Munshi, Jayati; Stewart, R; Ismail, K; Bebbington, P E; Jenkins, R; Prince, M J. Epidemiological data from uncontrolled studies suggest that 17.8 to 39 per cent of patients with type 2 diabetes mellitus (T2DM) suffer from depression3. The first group was genetically manipulated to disrupt the DISC1 gene only in the mouse’s pancreatic beta cells. effect of lifetime psychiatric illness on diabetes-related HRQOL; F = 46.8; df = 3, 135; p < 0.005). We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment. Additional research, including a report from the Canadian Diabetes Association (CDA), generally corroborates the study findings because it says that people diagnosed with serious mental illnesses, such as bipolar disorder and schizophrenia, do have a higher risk of developing diabetes than the general population. For confidentiality purposes, we use the general descriptors of Northern Plains and Southwest rather than specific tribal names. The most common diagnoses were anxiety (N = 32; 15.5%) and mood disorders (N = 8; 3.9%). Diabetic adults have significantly higher prevalence of diagnosed mental disorders and psychological distress than non-diabetic subjects. Interestingly, the heightened risk for psychiatric disorders peaked with children born between 1973 and 1986 and then declined.