[ Diabetes Type 2 ]

PRP for Diabetic Ulcer

Optimal medical treatment of ischemic diabetic ulcers is multifactorial. Charles M. As a result, foot ulcers are a major cause of hospitalizations and additional healthcare expenditures in this population and have been linked with a three-year cumulative mortality rate of 28 percent.2 This article considers recently published data related to the cumulative costs associated with the medical management of diabetic foot ulcers (DFUs). The Lothian and Forth Valley Study of 600 patients with leg ulceration reported that 76% had venous disease and 22% had arterial disease. According to a new study published in the Journal of Investigative Dermatology, researchers might be able to use ultrasound to treat diabetic skin wounds. Ulcers were considered healed if they showed complete skin closure with no drainage. If the sensation in your foot is lost or reduced, you may not feel if you damage your feet.

Increasing arterial perfusion if the patient is unsuitable for reconstructive surgery or angioplasty is desirable. By week four of treatment, complete healing had occurred in 85% (17/20) patients receiving EpiFix, 35.0% (7/20) patients receiving Apligraf, and 30% (6/20) patients receiving standard care, the team found (p=0.001 for EpiFix versus Apligraf and for EpiFix versus standard care). All patients were assigned an index date. There may be signs of stasis dermatitis around the ulcer. Bass and his team are now recruiting participants for human trials, and they could begin clinical treatment in as little as three years. Foot ulcers are a serious concern in diabetics because they can take a long time to heal. You are also more likely to have infections in the ulcer.

Necrotic wounds are dryed until surgical revascularization, or excised if they are limited and superficial. Before you would notice a ulcer on the foot, there would be reddening of the skin, blistering, and other signs of irritation. Differences in average emergency room costs were substantial across both groups ($5,346 compared to $2,924) as were average home healthcare costs ($4,390 compared to $2,283). These are often under calluses or over pressure points such as the plantar aspect of the first or fifth metatarsophalangeal joint. Additionally, some research has found that ultrasound isn’t effective in healing all forms of wounds. You may run a high temperature. Your blood sugar levels may also be elevated.

Reducing plantar pressure is always necessary. Regular health checks and monitoring of blood glucose levels is very important if you are a diabetic. It comprehensively extracted the differences in the healthcare experiences and costs of those Medicare beneficiaries with diabetes who sustained a DFU and compared them against the healthcare utilizations of closely matched peers who did not sustain an ulcer. Assess the edge of the ulcer (shallow, punched out, rolling). Infections, especially those that have reached the bone, must be treated surgically. Applying pressure on the ulcer should be avoided during its healing period because the new tissue is extremely delicate. The wound is treated with compression of the leg to minimize swelling.

Compression treatments include moist to moist dressings, hydrogels, alginate dressings, collagen wound dressings, debriding agents, antimicrobial dressings, and composite dressings. Hyperbaric oxygen therapy is also used for treating diabetic ulcers where the patient is exposed to 100% oxygen and 2 to 3 times the normal atmospheric pressure. Had these severely sick and costly patients remained in the DFU sample, the cost differential would have leapt from $11,710 to $18,756.2 Thus, the 12-month healthcare costs associated with a DFU are even higher when the most compromised beneficiaries with the highest healthcare utilization histories are included. Examination of the pulse should be performed and a record taken of blood pressure and body mass index. Complications include having decreased sensation in the limbs and a decreased blood supply (ischaemia) to the limbs. Diabetic patients with ischaemic foot ulcers have the worst outcome of all chronic skin wounds. Surgery to heal diabetic ulcers can include tenotomy, tendon lengthening, reconstruction surgery, or removal of bony prominences of the foot, but these procedures may result in a secondary ulceration.


Also, along with secondary ulceration, some other complications may also arise. The recurrence rate for diabetic ulcers is also very high. Once these individuals are identified, it is important to note that the direct costs associated with the treatment of the ulcer ultimately represented less than half of the additional healthcare expenditures experienced by these individuals. The patient must be educated about the origin of the ulcer. It is safe due to its autologous nature (derived from same person). Growth factors are proteins that play an important role in wound healing. Without functional growth factors, an ulcer can get stuck in a non-healing phase and will be very difficult to heal on it’s own.

There have been many studies conducted on the efficacy and safety of using platelet rich plasma over the years to treat diabetic foot ulcers, and most of them have concluded that the patients had complete healing. The procedure is safe and there are no serious adverse effects of this therapy. in 2012. Do not go around with bare feet. Platelets contain a large numbers of different types of growth factors. When applied topically on the ulcer, this preparation promotes rapid vascularization of the healing tissue and, because it is autologous, it eliminates concerns about immunogenic reactions and disease transmission. Approximately ≤ 20 ml of blood is collected from the patient depending on the size of the ulcer and is placed in a centrifuge for 15 minutes.

A centrifuge spins the blood to separate the platelets. The platelet concentrate is then mixed with a reagent (thrombin) to create a gel-like substance which is applied directly to the wound. 2014. A contact layer dressing will then be applied over the gel. A foam dressing is then placed over the contact dressing so that PRP gel is not absorbed. To protect it from slipping out, a barrier cream is generally placed on the intact skin surrounding the wound. Foot ulcers are an expensive problem.

A healed ulcer greatly improves the poor quality of life caused by a foot ulcer, whereas a non healing ulcer reduces the quality of life for both patients and his/her caregiver. Cost of amputation is high which involves the surgery cost and cost of hospitalization stay. 1999. All coupled together, this is a significant cost to the patient. PRP therapy, on the other hand, can be applied in an outpatient or clinic medical setting which represents cost effectiveness for patients. Several studies have concluded the use of PRP gel results in improved quality of life and lowered cost of care as compared to other treatment modalities for nonhealing diabetic foot ulcers. Wearing shoes that fit properly, and regular inspection of the feet helps in reducing the risk of having a diabetic foot ulcer.

Good foot hygiene is crucial. There are diabetic shoes available on the market today for all sizes. 1998. If left untreated, the ulcer may get infected which may increase and spread to the body. There will be loss of function and ability to perform daily activities. Amputation of involved foot or leg may be required in later stages due to gangrene. After one limb has been amputated, the opposite limb is often lost within a few years because of the ongoing problems and vascular disease; also the opposite leg has to bear increased pressure and workload.

Questions you should ask your doctor about Diabetic Ulcer What is diabetic foot ulcer? What are common problems that may lead to a diabetic foot ulcer? What tests may I have to undergo when I have a diabetic foot ulcer? Is this treatable? How would you treat it? Do I have to be on bedridden until it is healed? What medications will I have to take?

Will I need to alter my diet during the healing process? How can I prevent it occurring on my other foot? What more can I do to control my diabetes? How can special shoes help my feet? How can diabetes harm my skin? Have there been any recent advancement’s in treatment for the diabetic foot?

Tags: , ,