[ Nutrition ]

Physical activity and the risk of gestational diabetes mellitus: a systematic review and dose-response meta-analysis


Introduction: Diabetes mellitus (DM) type II is a chronic disease with high prevalence of morbidity and mortality therefore associated with high costs at primary health care level (Kalofoutis, Piperi, Kalofoutis, Harris, Phoenix & Sing, 2007). © Oxford University Press, 2015. SID Study Groups, AMD Study Groups, SID, AMD and Diabete Italia Interassociation Groups; Mariano Agrusta, Angelo Avogaro, Enzo Bonora, Emanuele Bosi, Paolo Brunetti, Daniela Bruttomesso, Tiziana Bufacchi, Franco Burla, Anna Cantagallo, Carlo Caravaggi, Anna Ciardullo, Marco Comoglio, Renzo Cordera, Carlo Coscelli, Gaetano Crepaldi, Paolo Di Berardino, Sergio Di Pietro, Katherine Esposito, Ezio Faglia, Danila Fava, Massimo Federici, Francesco Galeone, Aldo Galluzzo, Stefano Genovese, Luigi Gentile, Sandro Gentile, Paolo Gentili, Annalisa Giancaterini, Marta Letizia Hribal, Renato Lauro, Davide Lauro, Luigi Laviola, Luca Lione, Stanislao Lostia, Giuseppe Marelli, Massimo Massi Benedetti, Roberto Mingardi, Valerio Miselli, Claudio Noacco, Massimo Orrasch, Giuseppe Paolisso, Gabriele Perriello, Gianluca Perseghin, Piermarco Piatti, Giuseppe Pipicelli, Andrea Pizzini, Antonio Ettore Maria Pontiroli, Massimo Porta, Guido Pozza, Paolo Pozzilli, Francesco Purrello, Donata Richini, Angela Rivellese, Carlo Maria Rotella, Giuseppe Sanfilippo, Alessandro Sergi, Anna Solini, Marco Songini, Vincenza Spallone, Sebastiano Squatrito, Paolo Tessari, Antonio Tiengo, Laura Tonutti, Mariella Trovati, Natalia Visalli, Ivana Zavaroni. Prevalence rates were estimated considering known cases and newly found ones together. Mean age of the sample was 65.4 years and 56.7% were men. The mean age at onset of puberty (Tanner stage II) was 12 +/- 1 years in girls and 13 +/- 1 years in boys. The UKPDS (United Kingdom Prospective Diabetes Study) 62 remains the largest and most influential trial of intensive glycemic control in persons with newly diagnosed, mainly clinically detected, type 2 diabetes.

Expression levels of osteogenic marker genes and transcription factors were altered, e.g. Randomization was stratified by geographic region and renal function (normal or mild renal impairment, moderate renal impairment, and severe renal impairment including end-stage renal disease). The LSMD for changes in FPG was −1.24 mmol/L (95% CI, −1.75 mmol/L to −0.73 mmol/L) and −1.92 mmol/L (95% CI, −2.43 mmol/L to −1.41 mmol/L) for canagliflozin 100 mg and 300 mg, respectively. There was some indication of inverse associations between walking (before and during pregnancy) and vigorous activity (before pregnancy) and the risk of gestational diabetes mellitus. This meta-analysis suggests that there is a significant inverse association between physical activity before pregnancy and in early pregnancy and the risk of gestational diabetes mellitus. He had desirable health status up to 1 week prior to admission.

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