[ Diabetes Type 2 ]

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted


A stepwise selection procedure, adjusting for age and sex, was used in 2693 subjects with complete data to determine which risk factors for coronary artery disease should be included in a Cox proportional hazards model. 358, Hôpital St Louis, Bâtiment INSERM, 12 rue de la Grange aux Belles, 75010 Paris, France †The Wellcome Trust Centre for Human Genetics, Windmill Road, Oxford 0X3 7BN, UK ‡Service d’endocrinologie, Hôpital St Louis £INSERM U93, Hôpital St Louis, 1 Av. Obesity, physical inactivity and high-fat diet have been found to predict IGT and NIDDM. Mesial and distal bone loss was measured from panoramic radiographs and mean alveolar bone loss was calculated. Lat. TP was performed in 5 male cynomolgus monkeys (Macaca fascicularis). 1.25(OH)2D and intact PTH did not rise during stimulatory test.

In the Central, Eastern and Western Provinces, female diabetics had a significantly higher HT prevalence compared to male diabetics, however, in the Southern and Northern Provinces, the prevalence rate was almost the same. Of adhesion molecules, ICAM-1, VLA, VCAM, and LFA-3 were normal and only ICAM-1 was moderately overexpressed in and around the islets of case 1 insulitis, as was detected by immunofluorescence which showed that 18% of the islets of case 1 had CD8+ lymphocytes as the predominant population. Reverse transcription-PCR demonstrated moderate V beta skewing and the profile of cytokines expected in CTLs: IL-2, IL-4, IL-10, and IFN-gamma negative, perforin positive. In addition, IFN-alpha, IFN-beta, and IL-6 transcripts were detected in the case 1 pancreas, consistent with the existence of a silent viral infection. Overall, the results indicated that, differently from spontaneous animal models of diabetes, in the pancreas of IDDM patients there are no elements of the inductive phase of the autoimmune response.

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[ Diabetes Type 2 ]

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted


Surgeons were in the past reluctant to embark upon pancreatic resection because of technical difficulties and frequent post-operative complications. Nerve growth factor (NGF) is one of the most extensively studied neurotrophic factors, which is produced and released by numerous cells including the pancreatic beta cells. Lymphocytes and immunoglobulins are excluded by the membrane and unable to cause rejection of the islets. By serotyping of the HLA antigens, DNA typing of HLA-B and HLA class II loci, and study of polymorphic DNA markers of chromosome 6, Abramowicz et al. Patients with this disorder are unique in that they have low glucagon levels that respond abnormally to several physiological stimuli, blunted epinephrine responses to insulin-induced hypoglycemia, and malabsorption. Use of the antidiabetic drug metformin has been associated with reduced risk of pancreatic cancer in diabetics and recognized as an antitumor agent with the potential to prevent and treat this cancer. In case 1, there was “inappropriate” HLA class II expression in islets cells but it was a rare finding and not beta cell specific.

The two comparison series were remarkably similar with respect to the whole spectrum of the study variables. Of adhesion molecules, ICAM-1, VLA, VCAM, and LFA-3 were normal and only ICAM-1 was moderately overexpressed in and around the islets of case 1 insulitis, as was detected by immunofluorescence which showed that 18% of the islets of case 1 had CD8+ lymphocytes as the predominant population. The beneficial effect on glucose control has been individually described both for SPK [16] and SIK patients [4]. Future studies of pancreas transplantation must incorporate more rigid experimental controls than have been used in the past to better assess the relative merits of this procedure. 2007).

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