A stepwise selection procedure, adjusting for age and sex, was used in 2693 subjects with complete data to determine which risk factors for coronary artery disease should be included in a Cox proportional hazards model. 358, Hôpital St Louis, Bâtiment INSERM, 12 rue de la Grange aux Belles, 75010 Paris, France †The Wellcome Trust Centre for Human Genetics, Windmill Road, Oxford 0X3 7BN, UK ‡Service d’endocrinologie, Hôpital St Louis £INSERM U93, Hôpital St Louis, 1 Av. Obesity, physical inactivity and high-fat diet have been found to predict IGT and NIDDM. Mesial and distal bone loss was measured from panoramic radiographs and mean alveolar bone loss was calculated. Lat. TP was performed in 5 male cynomolgus monkeys (Macaca fascicularis). 1.25(OH)2D and intact PTH did not rise during stimulatory test.
In the Central, Eastern and Western Provinces, female diabetics had a significantly higher HT prevalence compared to male diabetics, however, in the Southern and Northern Provinces, the prevalence rate was almost the same. Of adhesion molecules, ICAM-1, VLA, VCAM, and LFA-3 were normal and only ICAM-1 was moderately overexpressed in and around the islets of case 1 insulitis, as was detected by immunofluorescence which showed that 18% of the islets of case 1 had CD8+ lymphocytes as the predominant population. Reverse transcription-PCR demonstrated moderate V beta skewing and the profile of cytokines expected in CTLs: IL-2, IL-4, IL-10, and IFN-gamma negative, perforin positive. In addition, IFN-alpha, IFN-beta, and IL-6 transcripts were detected in the case 1 pancreas, consistent with the existence of a silent viral infection. Overall, the results indicated that, differently from spontaneous animal models of diabetes, in the pancreas of IDDM patients there are no elements of the inductive phase of the autoimmune response.