[ Nutrition ]

One in four has alarmingly few intestinal bacteria – University of Copenhagen

A team of Chinese and Danish researchers has identified 500 new species of gut-residing microorganisms and 800 new bacterial viruses which could attack them. The process involves bacterial toxins, such as the LPS-layer of E. Belonging to one group or another seems to be linked to a tendency towards obesity or to develop diabetes. Have chronic health problems such as diabetes, cancer, or liver or kidney disease. This was discovered to be possible with a single factor, the full-length form of glucagon-like peptide-1 (GLP-1), a 30-amino acid peptide hormone produced in the intestinal epithelial endocrine L-cells that increases insulin secretion from the pancreas. Type 2 treatment “What we are finding is that as people gain weight, they are increasingly likely to be colonized by staph bacteria – to have large numbers of these bacteria living on the surface of their skin,” added Schlievert. Notably, the patients had significantly higher frequencies of Stenotrophomonas maltophilia clones in their sera compared to the healthy controls.

You may see claims suggesting that probiotics can “treat” or “cure” any number of health problems. -The genetic analysis of intestinal bacteria from 292 Danes shows that about a quarter of us have up to 40% less gut bacteria genes and correspondingly fewer bacteria than average. After only 2 weeks, the animals began to lose the ability to respond to glucose, a condition that worsened throughout the experiment. Because the composition of enteric microbes varies with the environment and diet, mice with the same genetic background can have different gut bacteria, and presumably this was the case for the TLR2-deficient mice in previous studies. Oluf Pedersen compares the human gut and its bacteria with a tropical rainforest. Our results show at baseline a negative correlation between bacterial DNA levels and fasting blood glucose. It appears that the richer and more diverse the composition of our intestinal bacteria, the stronger our health.

The bacteria produce vital vitamins, mature and strengthen our immune system and communicate with the many nerve cells and hormone-producing cells in the intestinal system. However, LF had no protective effect against the mortality of diabetic mice infected with a lethal dose of E. This study stems from earlier work by – and draws data from – the MetaHIT consortium, an EU-funded project which ran from 2008 to 2012 and which aimed to establish associations between the genes of microbes in the human gut and our health and disease. While cholera can be treated in modern times with oral rehydration therapy, it is still a massive killer in the developing world, especially of children. -And we also see that if you belong to the group with less intestinal bacteria and have already developed obesity, you will also gain more weight over a number of years. One key mediator of the microbiome’s effect on inflammation appears to be regulatory T-cells. In contrast, the immortalized fat cells allow experiments to be repeated multiple times on identical cells ensuring consistent, reproducible results.

Overactive clotting is also a feature of inflammatory conditions like rheumatoid arthritis and Alzheimer’s. -This indicates that you can repair some of the damage to your gut bacteria simply by changing your dietary habits. Since then, he has identified nearly 20 different superantigens and shown that they cause the deadly effects of various staph infections, including sepsis and endocarditis, a serious infection of heart valves. Over the next years, we will be gathering more knowledge of how best to do this,” says Oluf Pedersen, whose research team is studying, among other things, the impact of dietary gluten on gut bacteria composition and gut function. Although it has long been known to improve insulin and metabolic signaling, recent science suggests that metformin may beneficially alter the gut microflora. There are likely many causal factors at play. But the MetaHit researchers’ contribution opens a new universe in which we begin to understand how gut bacteria in direct contact with the surrounding environment have a decisive impact on our health and risk of disease.

-At present we cannot do anything about our own DNA, individual variation in which also plays a crucial role in susceptibility for lifestyle diseases. But thanks to the new gut microbiota research, we now can start exploring interactions between host genetics and the gut bacteria- related environment which we may be able to change. That is why it is so exciting for us scientist within this research field– the possibilities are huge, says Oluf Pedersen. -The long-term dream is to map and characterize any naturally occurring gut bacteria that produce appetite-inhibiting bioactive substances and in this way learn to exploit the body’s own medicine to prevent the obesity epidemic and type 2 diabetes, says Oluf Pedersen.

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