[ Diabetes Type 2 ]

Night-time Symptoms

Clinical conditions associated with the loss of normal diurnal variation in solute excretion or loss of renal concentrating ability result in nocturia without polyuria. Nocturnal Polyuria is an important cause of nocturia in which there’s an overproduction of urine at night. Type 2 diabetes mellitus (T2DM) is also associated with nocturia. Desgranchamps F, Cortesse A, Rousseau T, Teillac P, Duc AL: Normal voiding behaviour in women. Obayashi’s group found that higher UME levels were significantly associated with a decreased likelihood for nocturia. Diabetes often causes frequent urination because of the diuretic (water pill) effect of glucose. Patients responded rapidly with a fall in blood glucose levels from 456 +/- 12 mg/dL at baseline to 202 +/- 10 mg/dL at 1 week to 120 +/- 5 mg/dL at 4 months.

It is very common to see nocturia in patients with OSA, and it is something I am sure to ask about in patients who have symptoms. Reduced bladder capacity may be a result of idiopathic or neurogenic detrusor overactivity, bladder outlet obstruction, or reduced nocturnal bladder capacity. Ferring then performed two very similar placebo-controlled trials, one for women, and another for men — with an even lower dosage for female subjects. The authors reported finding no differences in age, prostate volume, transitional zone volume, prostate-specific antigen level, voided volume, or maximum flow rate between the diabetes and control groups. Pregnant women and elderly are more at risk for suffering from nocturia and its adverse outcomes. Have you also had any pain or burning whilst passing urine or any other symptoms like stomach pain and stomach tenderness? If diabetes is suspected, the patient will be referred to an endocrinologist.

Mary Umlauf, a professor at the University of Alabama Capstone College of Nursing in Tuscaloosa and a noted nocturia researcher, said the study could play an important role in dispelling “old wives’ tales” about nocturia. The treatment of these symptoms should be catered according to the cause indentified. When it comes to this particular disorder, medical researchers have been able to identify two conditions that are associated with nocturia (these are global polyuria and nocturnal polyuria). Diabetics lose sugar molecules in the urine. These sugar molecules attract water molecules and hence result in a larger volume of urine made. In those with poorly controlled diabetes, they should seek specialist help to achieve better sugar control. The fluid that accumulates in the legs all day in those with leg swelling, is redistributed in the body and excreted in the urine when that person lies down flat in bed at night.

These patients may benefit from the use of compressive stockings during the day, leg elevation during the afternoon and reduction in salt intake. Once the receptors are blocked the bladder then can relax so overactivity does not occur.Solifenacin. Pregnant women and women who had given birth within the last 6 mo were rescheduled to have study visits at least 6 mo after delivery. Medications such as a bladder-calming drug (for OAB) or ADH (anti-diuretic hormone) may be useful in some cases. Medications can be helpful in some patients. In those with an overactive bladder, medications to calm the bladder can be effective. in press.

There is a risk in electrolyte imbalance (low sodium) and exacerbating heart failure, so it is generally not recommended in the elderly. Surgery may be indicated if the underlying problem is prostatic obstruction in men. In patients with overactive bladder who do not respond to medications, Anti-spasm bladder injection or sacral neuromodulation (bladder pacemaker) may be tried.

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