The levels of both DHEA and DHEA-S were inversely associated with the age-adjusted risk for a CHD event. It is also one of the most reliable bio-markers of aging. DHEA levels in the body begin to decrease after age 30, and are reported to be low in some people with anorexia, end-stage kidney disease, type 2 diabetes (non-insulin dependent diabetes), AIDS, adrenal insufficiency, and in the critically ill. RESEARCH DESIGN AND METHODS—Relationships of urinary albumin excretion to serum DHEA sulfate (DHEA-S) concentration and to major cardiovascular risk factors, including blood pressure, serum lipid concentration, glycemic control (HbA1c), and BMI, were investigated in 357 consecutive men with type 2 diabetes. Safety and effectiveness have not always been proven. In addition, DHEA causes significant increases of cytosolic Ca(2+) concentrations and a parallel activation of protein kinase C (PKC)-beta(2). The sulfated form of DHEA, called DHEAS, is only produced by the adrenal glands The adrenal glands are stimulated by adrenocorticotropic hormone (ACTH) and prolactin, produced by the pituitary gland.
The ratio of DHEAS/testosterone is an important regulator of insulin sensitivity and glucose tolerance and that DHEA therapy may be beneficial in the treatment of certain forms of insulin resistance. At the end of the study, diabetics who had taken DHEA had 50% less oxidative stress and glycation and significantly more antioxidants in the blood, including 35% more glutathione and 76% more vitamin E. On the other hand, most women can actually benefit from an increase in estrogen, and this is where DHEA can help; plus there are many other benefits of taking DHEA. When collagen is increased not only does the skin look more youthful but there are the benefits to joints and even blood vessels.