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Meta-Analysis And Meta-Regression Of The Prevalence Of Diabetic Peripheral Neuropathy Among Patients With Type 2

Explain the pathophysiology of diabetic peripheral neuropathy (DPN). Diabetic people no longer produce insulin or their bodies no longer react to it or react inadequately. Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy; mononeuropathy; mononeuropathy multiplex; diabetic amyotrophy; a painful polyneuropathy; autonomic neuropathy; and thoracoabdominal neuropathy. RESEARCH DESIGN AND METHODS Adults aged ≥40 years (n = 2,514) were evaluated in the 2001–2004 National Health and Nutrition Examination Survey for clustering of two or more cardiometabolic characteristics, including elevated triglycerides or plasma glucose, low HDL cholesterol levels, increased waist circumference, or hypertension. The “moving wall” represents the time period between the last issue available in JSTOR and the most recently published issue of a journal. T2-weighted fat saturated cross sectional SPAIR MR Image (0.3 × 0.3 × 3 mm3) of (B) a diabetic type 2 patient with neuropathy and (C) a diabetic … The participants walked at their own pace along the walkway and stopped in front of a marked stopping line while kinetic and kinematic data were recorded.

Diabetes mellitus (DM) is a chronic disease of hyperglycemia associated with metabolic syndrome, which is characterized by insulin resistance [1]. Diabetic peripheral neuropathy development was significantly more frequent in participants presenting with cardiovascular disease at baseline (P=0.01). The relationship between glycemic variability and diabetic peripheral neuropathy in type 2 diabetes with well-controlled HbA1c. Nerve conduction studies are considered by many as the “gold standard” for nerve damage and the most consistent indicator of (sub-)clinical neuropathy [6]. 2014;6(1):139. Wu J, Zhang X, Zhang B. Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials.

Student’s t-test was used in comparison of 2 independent groups of normally distributed variables; one-way analysis of variance (ANOVA) test was used when comparing more than 2 groups; and LSD test was used for paired comparisons to identify which group the difference was caused by. 2014;34(4):401-10. The inclusion criteria were adults (> 18 years) with type 2 diabetes for at least 12-months. A Comparative study of examination scores and quantitative sensory testing in diagnosis of diabetic polyneuropathy. Int j diabetes dev ctries. Finally, total loss of feeling occurs. Diabetes can lead to many complications.

Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. Although each of these components in itself is a risk factor for cardiovascular disease and other related outcomes such as PVD, their aggregation or “clustering” may result in a greater overall disease risk (14,15). 2011;343:d4002. Acker K, Bouhassira D, Bacquer D, Weiss S, Matthys K, Raemen H, et al. Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics. Subsequently, a composite score has been introduced for quantitative analysis of the results of NCS [8]. 2009;35(3):206-13.

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Percent body fat was estimated by bioelectric impedance, using Tanita Body Composition Analyzer; model TBF-410 (Tanita Corporation, Tokyo, Japan). Charles M, Ejskjaer N, Witte DR, Borch-Johnsen K, Lauritzen T, Sandbaek A. Prevalence of neuropathy and peripheral arterial disease and the impact of treatment in people with screen-detected type 2 diabetes: the ADDITION-Denmark study. Nonetheless, it is loss of sensation and creates a teaching opportunity for the importance of foot care and callus removal. A neurologist will most likely come to the same conclusion. Codogno JS, Fernandes RA, Sarti FM, Freitas Junior IF, Monteiro HL. The burden of physical activity on type 2 diabetes public healthcare expenditures among adults: a retrospective study.

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2013;30(6):694-701. Treatment should start with glycemic management. Peripheral neuropathy in type 2 diabetes mellitus in Isfahan, Iran: prevalence and risk factors. Acta neurol scand. 2006;114(6):384-91. Jianbo L, Yuche C, Ming S, Jingrong T, Qing D, Yu Z, et al. Association of homocysteine with peripheral neuropathy in Chinese patients with type 2 diabetes.

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Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes. Clin endocrinol. 2005;63(3):317-22. Liu F, Bao Y, Hu R, Zhang X, Li H, Zhu D, et al. Screening and prevalence of peripheral neuropathy in type 2 diabetic outpatients: a randomized multicentre survey in 12 city hospitals of China. Diabetes metab res rev. Preventing the pain and agony of neuropathy is ideal, but treating this devastating complication is critical.

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2009;14(1):1-13. Pradeepa R, Rema M, Vignesh J, Deepa M, Deepa R, Mohan V. Prevalence and risk factors for diabetic neuropathy in an urban south Indian population: the Chennai Urban Rural Epidemiology Study (CURES-55). Diabet med. 2008;25(4):407-12. Sloten TTV, Savelberg HH, Peeters IGD, Meijer K, Henry RM, Stehouwer CD, et al. Peripheral neuropathy, decreased muscle strength and obesity are strongly associated with walking in persons with type 2 diabetes without manifest mobility limitations.

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The association between cardiac autonomic neuropathy with metabolic and other factors in subjects with type 1 and type 2 diabetes. J diabet complications. 2011;25(3):159-67. Mahroos FA, Roomi KA. Diabetic neuropathy, foot ulceration, peripheral vascular disease and potential risk factors among patients with diabetes in Bahrain: a nationwide primary care diabetes clinic-based study. Ann saudi med. 2007;27(1):25-31.

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2010;64(2):51-7. Hussain G, Rizvi SA, Singhal S, Zubair M, Ahmad J. Cross sectional study to evaluate the effect of duration of type 2 diabetes mellitus on the nerve conduction velocity in diabetic peripheral neuropathy. Diabetes metab syndr. 2014;8(1):48-52. Abbott CA, Garrow AP, Carrington AL, Morris J, Van Ross ER, Boulton AJ. Foot ulcer risk is lower in South-Asian and african-Caribbean compared with European diabetic patients in the U.K.: the North-West diabetes foot care study.

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