[ Diabetes Type 2 ]

Medline ® Abstract for Reference 16 of ‘The adult patient with brittle diabetes mellitus’


The goal in treating diabetic cats is to regulate blood glucose levels. A successful PTA—in contrast to intensive insulin regimens and insulin pumps—restores normoglycemia without the risk of hypoglycemia and prevents, halts, or reverses the development or progression of secondary diabetes complications. However, diabetes is not one condition, rather a collection of metabolic diseases that affect either the way the body uses insulin or the way it makes it. We identified 10 survivors of an original cohort of 33 brittle type 1 patients, recruited between 1979 and 1985. Even more than the other kinds of diabetes, therapy is based on education, glycemic control, intensive therapy and strict interaction between physicians and patients. Clinical Presentation & Morbidity Pattern Adult patients present with symptoms and signs suggestive of long standing hyperglycaemia. The success of insulin pump therapy depends on selection of the right candidate, extensive education, motivation, and implementing the sophisticated programs with skill.

However, if an “abnormal” glucose response to the insulin challenge tests was observed, the location of the insulin resistance was identified as being subcutaneous, intravascular, or at the peripheral tissue. The differential diagnosis included infection (pyomyositis, necrotic fasciitis), focal inflammatory myositis, vascular events, trauma, tumor and diabetic amyotrophy, all of which were excluded. This applies also to –        Brittle Diabetes Mellitus in children; and, –        Diabetes Mellitus in pregnancy or diabetes mellitus as a cause of female infertility and habitual pregnancy loss.

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