Sulfotransferase (SULT) function has been well studied in healthy human subjects by quantifying mRNA and protein expression and determining enzyme activity with probe substrates. Twenty seven individuals (16M/11F) participated in two separate randomized single-blind, 2 day protocols. DHEA has its own hormone effects. We used the random-effects model to pool across studies and evaluated heterogeneity using the I(2) statistic. Take this medicine by mouth with a glass of water. Thirteen men and 17 women between 40 and 70 years of age took 50 milligrams of DHEA per day for six months. Scientists noted that DHEA had prevented oxidative stress in other studies and wanted to test its effect in diabetes.
This suggests that DHEA may act in insulin-resistant mutant mice and in aging normal mice to increase the sensitivity to insulin. DHEA also appeared to counteract bone loss caused by medication and increase bone density. DHEA may interact with agents for Alzheimer’s and arthritis; agents for the brain, heart, skin or urinary tract; agents that improve mental function; agents that may affect blood vessel width; agents that may affect GABA; agents that may affect the immune system; agents that may be toxic to the liver; agents that may lower seizure threshold; alcohol; androgens; angiotensin-converting enzyme (ACE) inhibitors; anticancer agents; antidepressants; antiestrogens; anti-inflammatories; antiobesity agents; antipsychotic agents; antiseptics; antiviral agents; aphrodisiacs; aromatase inhibitors; Bacillus Calmette-Guérin vaccine; benzodiazepines; beta-blockers; birth control; bronchodilators (increase air flow to lungs); bupropion; calcium channel blockers; calcium salts; canrenoate; cardiac glycosides; cholesterol-lowering agents; cocaine; corticosteroids; danazol; estrogens; fertility agents; gefitinib; gonadotropin-releasing hormone (GnRH) antagonists; growth hormones; hormonal agents or hormone replacement therapy (HRT); human chorionic gonadotropin; methylphenidate; metyrapone; morphine; NMDA receptor antagonists; opiate antagonists; osteoporosis agents; oxytocics; stimulants; tadalafil; thyroid hormones; vaccines; and vitamin D analogs. The severity of diabetes can be significantly decreased with DHEA treatment. Contrary to what the pharmaceutical companies formulating DHEA supplements as a prescription drug would like you to believe, DHEA supplements are not diet pills. Cleare et al.36 found higher basal DHEA levels in CFS patients with no psychiatric comorbidity compared to healthy controls; however, they did not report any differ- ence in DHEAS levels. DHEA wanes as we age; blood levels peak at about age twenty to twenty-five in both men & women decline to less than 5% of this peak by age 80.
It was also noted that there was no improvement in insulin levels of both the groups. DHEA is often thought of as an adrenal hormone, which it is, however, DHEA is also made in the ovaries. Because of its “parent” hormone status, DHEA may increase the risk of hormone-driven cancers, such as those involving the breasts, prostate, ovaries, and uterus. DHEA levels also seem to be lower in people with certain conditions like depression. In order to examine the association between DHEA and coronary atherosclerosis, plasma DHEA and DHEA-S levels had been previously determined in 206 middle-aged patients undergoing coronary angiography.