[ Diabetes Type 1 ]

Laughter up-regulates the genes related to NK cell activity in diabetes. – PubMed


A hypothesis about the evolution of insulin-dependent diabetes mellitus (IDDM)-susceptibility alleles is proposed. Chief among the genes which influence T1D susceptibility are those encoded in the major histocompatibility complex, especially those encoding the class II HLA-DQ molecules.1, 2 Other non-HLA genes also contribute to risk, although for many of these, it has been difficult to confirm the original reports. “There was a whole furious debate that arose about this,” said Dr. Proportions of African, European, and Asian ancestry were estimated from the HapMap samples using structure for each individual to rule out spurious association due to population substructure. This seasonality affects our immune cells and the composition of our blood and fat tissue. It is a scientific project that could potentially revolutionize the field of diagnostic medicine by leveraging the strengths of two techniques — Genome Wide Association Studies (GWAS) and Machine Learning — from two very different disciplines. Liss’ “Diasporic Identities: The Science and Politics of Race in the Work of Franz Boas and W.

Earlier in the same set of experiments, the researchers discovered that muscle cells from people with type II diabetes already showed these telltale epigenetic alterations to their DNA, particularly in the PGC-1 gene, which orchestrates metabolic programmes critical to the burning of fat in mitochondria, the chambers in cells that generate energy. These results suggest that the laughter influences the expression of many genes classified into immune responses, and may contribute to amelioration of postprandial blood glucose elevation through a modulation of NK cell activity caused by up-regulation of relating genes.

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