Too much sugar in the blood for a long time causes diabetes problems. The research could help pave the way to new treatments for some of the most common complications association with diabetes. In either case, these elevated blood sugar levels can cause damage to the small blood vessels throughout your body, and most profoundly to those found in the eye. For the purposes of this website page we will focus on diabetic retinopathy. Aaron Baker, associate professor in the Department of Biomedical Engineering, and his research team will receive the funding from the DOD’s Congressionally Directed Medical Research Programs, created to foster novel approaches to biomedical research. The changes in retinal vessel diameter are one of the symptoms for diseases based on vascular pathology. Arteriolar blockage slows the delivery of oxygen and other nutrients that are required to maintain cell health.
The macula doesn’t function properly when it is swollen. The association makes no representation or warranty as to their accuracy or reliability. The ratio of vessel to vessel free area classified the normal and DR affected retinal images more significantly than other texture based features. This can deprive organs of the blood they need to function, potentially resulting in kidney disease or retinopathy, which cause blindness. But VEGFB alone had only moderate effect on obesity and did not solve the problem of excessive fat accumulation in the body. Damaged blood vessels can also contribute to kidney disease, which can affect up to one in three people with diabetes. Now, research using endothelial cells isolated from the small blood vessels in the brains of mice has revealed that carefully targeting minute quantities of hydrogen sulfide to the mitochondria inside cells using AP39 or AP123 restored the efficiency of the mitochondria and prevented hyperglycaemia-induced build up of free radicals.
To investigate the role of elevated blood glucose level on endothelial progenitor cell function, a group of researchers from Jagiellonian University in Poland have been examining the mechanisms and effects of diabetes and anti-diabetic drugs on endothelial progenitor cells. As diabetic retinopathy progresses, new blood vessels start to grow at the retina of the eye. Many more blood vessels are blocked, depriving several areas of the retina with their blood supply. When this ‘fuel’ is lost, mitochondria, cells, blood vessels and tissues are damaged. Disclaimer: AAAS and EurekAlert! “Some people find it amusing that a substance with such a bad reputation can produce these benefits, but nearly every cell in our body makes and responds to tiny amounts of hydrogen sulfide and we have at least three distinct pathways for making this gas in very small quantities so it is very important. “All these factors offer a perfect recipe for proliferation of diabetes.
The paper, ‘The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial in vitro’ is published in Pharmacological Research. Authors are Domokos Gerö, Roberta Torregrossa, Alexis Perry, Alicia Waters, Sophie Le Trionnaire, Jacqueline L. Whatmore, Mark Wood, Matthew Whiteman.