[ Diabetes Type 2 ]

Inhibitory Effect of Pregnancy on Counterregulatory Hormone Responses to Hypoglycemia in Awake Rat


To elucidate the mechanism of insulin resistance due to insulin counterregulatory hormones (ICRHs) and evaluate ICRH secretion kinetics, ICRH concentrations were measured and correlated with blood glucose levels in 28 type 1 diabetic patients. Counterregulatory hormone concentrations were measured during a glucose clamp with graded reductions of plasma glucose from 5.2 to 2.6 mmol/L. Therefore, this study was designed to examine three aspects of growth hormone’s ketogenic activity: first, whether growth hormone’s ketogenic activity can be entirely accounted for by its lipolytic effect; second, whether growth hormone’s ketogenic activity is rapid or delayed in onset; and third, whether growth hormone may exert ketogenic activity indirectly by altering the plasma concentration of other ketone body-regulatory hormones (i.e. In some ways, DKA can be seen as starvation in the midst of plenty. First, a decrease in plasma glucose cannot turn off endogenous insulin secretion (which is either insignificant or absent). Furthermore, the results suggest that there is a strong correlation between brain damage caused by hypoglycemia and cognitive deterioration. Moreover, their plasma glucagon response was blunted while plasma epinephrine, norepinephrine, growth hormone, and cortisol responses were similar in both groups.

Norepinephrine rose from 1.12 ± 0.35 to 2.44 ± 0.69 nmol/l and from 1.09 ± 0.07 to 1.74 ± 0.16 nmol/l in the last hour in the H-HY and H-EU groups, respectively (P < 0.05 for both; no difference between groups). During clamped euglycemia, ingestion of amino acids resulted in transient increases in glucagon concentrations, which returned to basal by the end of the study. The release of epinephrine, but not norepinephrine, is also blunted, especially during mild hypoglycemia. The move toward more aggressive insulin therapy to prevent long-term complications from diabetes increases the risk of exercise-associated hypoglycemia for some active people with diabetes, especially young patients.

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