[ Diabetes Type 1 ]

Importance of glucagon in mediating epinephrine-induced hyperglycemia in alloxan-diabetic dogs. – PubMed

is a blood glucose (sugar) level that is higher than your healthcare provider recommends. Hyperglycemia is an independent risk factor for mortality in both diabetic patients and nondiabetic patients with ACS. Diabetic rats exhibited reduced efficiency in tubular Na(+) reabsorption, increased urinary Na(+) excretion (diabetics, 3.12+/-0.27 mEq/day; controls, 1.25+/-0.14) and diminished values of plasma renin activity (diabetics, 3.34+/-0.44 ng/ml.h; controls, 8.64+/-0.79). The “moving wall” represents the time period between the last issue available in JSTOR and the most recently published issue of a journal. Insulin-mediated glucose metabolism was reduced by approximately 30% (P less than 0.001) in diabetic rats. Quantification of p27Kip1 positive glomerular cells showed a significant increase of these cells in db/db mice compared with non-diabetic db/+ animals. Removal of the kidney bearing the grafts promptly resulted in the normoglycemic recipients (n = 4) becoming diabetic again.

Compared with a 1.5% prevalence of diabetes in the age-matched general Dutch population, the prevalence of identified cases was significantly increased in the study population. Hyperglycemia in diabetes leads to cardiovascular complications induced by oxidative stress (1). The effect of somatostatin was reversed by infusing glucagon (10 ng . A unifying link across these mechanisms might be the increased free radical generation evoked by high glucose. After discharge from the hospital, subjects were followed prospectively for 5.0 ± 1.5 years. Aldose reductase is the first and rate-limiting enzyme of the polyol pathway and converts glucose to sorbitol in a nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reaction. A 100% FFA increase was observed in all three groups, indicating that the lipolytic effect of epinephrine was independent of glucagon.

In conclusion, in diabetic dogs, in contrast to normal dogs, epinephrine induced a marked and prolonged increase in glucose concentration and production mostly through a stimulation of IRG secretion.

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