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Histological changes in placental syncytiotrophoblasts of poorly controlled gestational diabetic patients. – PubMed


High levels of hormones being produced in the placenta, which connects a mother’s blood stream to the developing baby, impair the action of insulin in a mother’s cells, causing her blood sugar to rise. Being overweight (a body mass index (BMI) of >25 kg/m2) or obese (BMI of >30 kg/m2) are recognised risk factors for developing GDM in pregnancy [5–8] and confer a 1.3 to 4.8 increased likelihood of developing this condition [6, 8]. The aim of this study was to investigate the effects of a probiotic capsule intervention on maternal metabolic parameters and pregnancy outcome among women with gestational diabetes. Gestational diabetes is a type of diabetes that occurs in a pregnant woman who did not have the disease before becoming pregnant, the CDC explains. A sample size of 352 women (176 per group) was planned to have 80% power to detect reductions in risk of 35% or larger. Direct microscopy revealed that these various changes in syncytiotrophoblast structure were marked in the poorly controlled gestational placenta compared with overt diabetics, and could have been due to the presence of histochemical compounds e.g. See their doctor regularly.

Over a third of pregnant women in Australia are either overweight or obese [2, 6, 11] and prevalence is higher in rural and regional areas than in metropolitan areas [6, 26]; a prevalence of overweight and obesity of 65.5% has recently been reported in the pregnant population of north-east Victoria [6].

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