[ Nutrition ]

High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. – PubMed

Recent studies show that glucosamine infusion impairs endothelium-dependent blood flow in normoglycaemic rats. Herbs do gradually lose their properties the longer they are kept. In research done in mice, researchers at Joslin Diabetes Center have uncovered new clues about the role that glucosamine, another sugar that circulates in blood, can play in early embryonic development. Er zijn tegenstrijdige resultaten van studies over dit onderwerp, echter. Moreover, her work suggests an approach to developing stem cells that might help to strengthen future regenerative therapies for many diseases. Hal Scofield: And I was just sitting in a session and I thought does glucosamine cause diabetes and isn’t this going to be bad for people potentially because I had learned that at some point in my endocrine training and I went back and looked at the literature about glucosamine and insulin and diabetes and found out there was very little human work, it was almost all animal work but that glucosamine given in those studies to animals does cause insulin resistance which is really the major underlying problem in type 2 diabetes. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect.

Glucosamine Glucosamine is a key building block of cartilage that is derived from the sugar glucose, the main sugar found circulating in the blood stream. Next and most importantly, the researchers fed glucosamine to aging mice in addition to their normal diet. Glucosamine or chondroitin alone or in combination didn’t reduce pain in the overall group, although people in the study with moderate-to-severe knee pain were more likely to respond to glucosamine. However, if a non-cancerous cell happens to make errors in the assembly of its surface glycans, it too will be targeted for destruction, even if it is otherwise healthy. However, another study, using a different from of glucosamine (glucosamine sulfate), found that this preparation was beneficial in people with knee osteoarthritis. GlcN plus insulin (but not high glucose plus insulin) decreased ATP (10-30%) and UTP (>50%). GTP was not measured, but GDP increased.

The authors then described the effects of O-GlcNAc protein modification in cell culture studies of proangiogenic cell function. We have come to the following conclusions. 1) Chronic exposure to high glucose or GlcN in the presence of low insulin caused insulin resistance of glucose transport by different mechanisms. Glucosamine is a precursor to chondroitin, which is typically more expensive and slightly less well-absorbed. 3) Both agents may act distally to PI-3 kinase. 4) GlcN has metabolic effects not shared by high glucose. GlcN may not model HSP appropriately, at least in 3T3-L1 adipocytes.

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