Metformin is a biguanide used to treat type 2 diabetes mellitus and most commonly prescribed oral hypoglycemic agent. heart failure, recent heart attack, shock, or conditions that cause severe breathing difficulties); diabetic ketoacidosis (a life-threatening complication of diabetes that can occur when glucose is not available as a fuel source and fat is used instead, resulting in the accumulation of ketones resulting from the breakdown of fat); or diabetic comatose (unable to wake) or precomatose (leading up to coma) states. I was diagnosed T2 in June this year and was started on Metformin slow release, 500mg a day. Metformin is usually started once per day with either your morning or evening meal for 1-2 weeks. If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin and repaglinide. Do not begin to take linagliptin/metformin if you are 80 years old or older, unless lab tests show that you do not have decreased kidney function. In addition, the coating for the 500 mg and 850 mg tablets contains hypromellose and the coating for the 1000 mg tablet contains hypromellose and polyethylene glycol.
Side effects can be reported to the FDA here. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. Contact your doctor right away if you start to feel unusually cold or if you have a general feeling of being unwell. Consequences are severe and dehydration achieves a foothold in thelist of metformin side effects.Hypoglycemia – The impact of metformin extends to the occurrence of the disorder of hypoglycemia or reduced level of sugar in the blood stream. In a retrospective study of 50 women with PCOS treated with metformin (including 11 withimpaired glucose tolerance at baseline), impaired glucose tolerance persisted in 5/11 (45%) and reverted to normal in the remainder (6/11, 55%)over an average of 43 months of follow-up. A detailed history revealed that the patient had not taken any other drug or substance.  In fact, upon closer examination of warnings to health care professionals, it becomes clear that Metformin manufacturers provide physicians with a warning that also acts as a disclaimer.
The most common side effects of JANUVIA are upper respiratory tract infection, stuffy or runny nose and sore throat, and headache. Dinner will be slightly less affected–i.e. After adjustment for age and sex, the odds ratio (OR) for a final metformin dose of less than 1500 mg/day was found to be 2·76 (95% CI 1·38–5·53, P = 0·004) for chronic gastritis subjects. The side effects reported by those taking metformin are compared against any side effects experienced by those taking a placebo. Nonmedicinal ingredients: crospovidone, magnesium stearate, polyethyleneglycol, polyvinyl alcohol, povidone, talc, and titanium dioxide. HbA1c gives a good indication of glycaemic control over the previous two or three months. Tablets should be taken with food whenever possible to reduce the risk of nausea and vomiting.
Tablets should be taken with food whenever possible to reduce the risk of nausea and vomiting. Both conditions have the potential to produce lactic acidosis. To ensure that the medication is working well, monitor your blood glucose on a regular basis as directed by your doctor or diabetes educator. Liver and kidney function should be assessed before starting metformin and rechecked at least once a year while taking it. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. It is important to take this medication exactly as prescribed by your doctor. APPEARANCE OF INTACT CAPSULE IN STOOL This side effect only occurs when using the extended-release version.
If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions). Contact your doctor for instructions.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. Check your blood sugar levels as directed by your doctor. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. This not only helps in not getting lumps of fat at particular areas of our body but it also helps in the prevention of cardiovascular diseases. Many of these side effects can be managed, and some may go away on their own over time.
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. Many pharmacies will let you try a different generic brand if you want to try it. \ Alcohol intake: Anyone taking metformin should avoid excessive alcohol intake. Blood sugar control: If you have fever, trauma, infection, or surgery, you may have a temporary loss of blood sugar control. Blood sugar control: If you have fever, trauma, infection, or surgery, you may have a temporary loss of blood sugar control. Metformin may be started again after the problem is resolved.
Contact your doctor for instructions. Dye or contrast agents: If you are going to have an X-ray procedure that uses dye or a contrast agent, you may need to stop taking this medication for a short time. Contact your doctor for instructions. If you have severe kidney disease you are at higher risk of developing lactic acidosis. If you have severe kidney disease you are at higher risk of developing lactic acidosis. When it does occur (very rarely), it is fatal in 50% of cases. When it does occur (very rarely), it is fatal in 50% of cases.
There have been no reports of lactic acidosis in Canada when metformin was used as directed. If you experience symptoms of lactic acidosis (e.g., weakness, tiredness, drowsiness, unusual muscle pain, trouble breathing, stomach pain with nausea, vomiting or diarrhea, feeling cold, dizziness, light-headedness, or slow or irregular heartbeat), stop taking this medication and get immediate medical attention. Liver function: Decreased liver function has been linked to lactic acidosis. This medication is not recommended for people with severely reduced liver function. If you have moderately reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Low blood sugar: Under usual circumstances, low blood sugar does not occur for people who take only metformin. Low blood sugar could occur when not enough food is eaten, especially when strenuous exercise is undertaken at the same time or when large amounts of alcohol have been consumed.
Linagliptin/metformin is found in breast milk. If metformin fails to lower blood sugar to target levels, talk to your doctor. Your doctor may want to stop metformin or recommend another medication. Surgery: This medication should be stopped temporarily for surgery (except for minor surgery where food and fluid intake is not restricted). Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; dizziness or light-headedness; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness. Talk to your doctor for specific instructions. An interaction between two medications does not always mean that you must stop taking one of them.
Speak to your doctor about how any drug interactions are being managed or should be managed. Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.