Introduction: Gestational diabetes is an impaired glucose tolerance of variable severity first recognized in the current pregnancy. Glyburide and metformin therapies were reported to be comparable to insulin yet also cost-effective, patient-friendly, and potentially compliance-enhancing. Perinatal outcomes were compared using chi-square test and multivariable logistic regression models; statistical significance was indicated by p < 0.05 and 95% confidence intervals (CI). In the United States, traditional therapy for women with GDM who fail diet therapy has been insulin. Retroviral Disease Section, NCI, NIH Student Research Training Fellow, Summer 1995 Assisted with an epidemiological study of HHV8 in HIV-infected patients with and without Kaposi’s Sarcoma. It has also been demonstrated that glyburide is effluxed from the fetal to the maternal circulation by the breast cancer resistance protein (BRCP) and the humanmultidrug resistance protein 3 (MRP3). This drug stimulates the insulin secretion, which leads to normal blood glucose concentration. Results Eighty percent of the pregnancies were treated successfully with glyburide. Hormones such as placental lactogen and estrogen are produced in the placenta to help provide sustenance during the pregnancy. But all has been fine with her since. Good luck dear. In a 2007 meta-analysis, glyburide was compared with other anti-diabetic medications, including insulin, to determine whether it was associated with a higher risk of hypoglycemia.4 The meta-analysis, which included 21 studies, revealed a 52% higher risk of hypoglycemia in patients receiving glyburide compared with those taking other insulin secretagogues. That's why, my answer is not taking into account any other health problem you're facing that I don't know, but your ob knows.