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Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty


There are many people with Type 2 Diabetes that currently utilize the drug Byetta marketed by Eli Lilly and Amylin. The development of the ‘incretin concept’ which hypothesised that hormones from the gut contributed to the insulin secretion in response to meals, led to the identification of glucagon-like peptide 1 (GLP-1) as an important ‘incretin’ hormone. Exenatide, a synthetic chemical imitating a compound encountered in the venomous saliva of the Gila monster led to healthy sustained glucose levels and progressive weight loss among patients with type 2 diabetes, as revealed by a three-year study made on 217 diabetes patients. Still, loathing the creature is irrational; being careful around it is not. It produces only small quantities of its neurotoxic venom, which is secreted into the lizard’s saliva. Dat bleken er meer dan gedacht. “It was not clear that this was an approvability issue until we received the complete response letter,” Daniel M.

I think you’ll enjoy the answers we’re featuring today. Exendin-4 treatment was also associated in each of these experiments with weight loss and improved insulin sensitivity, as demonstrated by increases of up to 32 and 49%, respectively, in the glucose infusion rate (GIR) in the hyperinsulinemic euglycemic clamp. ED50s for weight loss and the increase in clamp GIR were 1.0 microg/kg+/-0.15 log and 2.4 microg/kg+/-0.41 log, respectively. As noted, gilas will have a variety of colors, spots, blotches or bands depending on the sub-species of lizard.

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