[ Diabetes Type 2 ]

Glomerular filtration and tubular reabsorption of albumin in preproteinuric and proteinuric diabetic rats.

The importance of albumin levels in regulation of glycation of plasma proteins is shown by a team led by Mahesh Kulkarni at CSIR-National Chemical Laboratory (www.ncl-india.org), Pune. The TBM from diabetics contained significantly more albumin (m +/ SD; 2.75 +/- 0.34 microgram/mg) than the TBM from other diseases (1.00 +/- 0.24 microgram/mg) or normals (1.21 +/- 0.26 microgram/mg) (P less than 0.0001). Wenzel, Department of Internal Medicine, Cardiology–Nephrology–Cardiovascular Research, A.Ö. 2. The development of type 2 diabetes, defined as a fasting glucose > or = 7.0 mmol/l and/or the use of antidiabetic medication, was used as the outcome measure. Results: Diabetic preimmunized groups for AGE-BSA, KLH, and AGE-BSA-KLH showed amelioration in renal function and histopathology compared with the diabetic control group. The frequency with which patients should be re-screened for M may be determined by the initial value of albumin excretion and by the threshold used to define M.

For example, if the current year is 2008 and a journal has a 5 year moving wall, articles from the year 2002 are available. Glomerular filtration rate was increased both in 7-10-d IDD (2.7 +/- 0.1 ml/min, P < 0.05) and in 50-70-d IDD (2.6 +/- 0.1 ml/min, P < 0.05) compared with control (2.2 +/- 0.1 ml/min). Calculated urinary space albumin concentrations increased early in IDD with 2.5 +/- 0.4 mg% in 7-10-d IDD and 4.9 +/- 0.6 mg% in 50-70-d IDD compared with control (1.4 +/- 0.3 mg%). The increase in filtration of albumin is in excess of that attributable to hyperfiltration before increased albumin excretion early in diabetes. *P ≤ 0.05 compared with nondiabetic controls. Full text Full text is available as a scanned copy of the original print version. Table 1 contains demographic characteristics of the study population. Furthermore, a study in nondiabetic pregnant women on correlations between glycemic control markers (A1C and serum glycated albumin) and iron deficiency status reported that in late pregnancy, A1C levels were increased because of iron deficiency, but serum glycated albumin levels were not influenced by such conditions (6).

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