[ Herbal Remedies ]

Glitazones et fonction pancréatique

Researchers at the London School of Hygiene and Tropical Medicine (LSHTM) in the United Kingdom have discovered that a drug typically used to treat people with diabetes can potentially offer relief from Parkinson’s disease as well. This may be due to the diabetic disease per se i.e., high as well as low insulin and glucose levels may cause direct effects on bone metabolism. During a period of Food and Drug Administration (FDA) advisories, rosiglitazone use declined sharply from 0.42 million monthly treatment visits (February 2007) to 0.13 million monthly visits (May 2008). The pharmacokinetic parameters such as Tmax, Cmax, AUC(0-α), t1/2, and Kel were determined by plotting the drug concentration as a function of time. This way of controlling glucose levels in type 2 diabetes has synergies with existing treatment options. Researchers used electronic health records from the UK Clinical Practice Research Datalink to match 44,597 glitazone users with 120,373 people using other antidiabetic drugs. Appraisals encompass information on clinical effectiveness, cost effectiveness, budget impact, and any wider NHS implications[2].

Clinicians, particularly pharmacists, must take an active role in educating colleagues on the importance of screening thiazolidinedione-treated patients for fracture risk, counseling patients on adequate calcium and vitamin D intake and fall prevention, and appropriately selecting therapy for secondary prevention of fracture. TZDs also increase the synthesis of certain proteins involved in fat and glucose metabolism, which reduces levels of certain types of lipids, and circulating free fatty acids. Conclusions: There are clinically important differences in risk of cardiovascular disease, heart failure, and all cause mortality between different diabetes drugs alone and in combination. Doctors and other medical practitioners please log in or register here. Jay Skyler. These drugs are known to increase the sensitivity of the body’s tissues to the action of insulin. Development of hyperglycaemia in type 2 diabetes requires insulin secretion abnormalities.

As the principal function of pancreatic β-cell is insulin secretion, mainly in response to a glucose stimulus, it is of an upmost importance to study abnormal β-pancreatic function during the development of type 2 diabetes. The animal model of choice for such studies is the ZDF (Zucker Diabetic Fatty) rat. Two hypothesis are commonly discussed to explain the progressive β-cell failure during type 2 diabetes evolution: glucotoxicity, mainly related to chronic hyperglycaemia effect on secretory β-cell function and to defective glucose utilization in skeletal muscles, and lipotoxicity, as a consequence of triglyceride accumulation in the islets of Langerhans. In fact, likely, these two phenomenons are linked together, this glucolipotoxicity leading to a cellular apoptosis, through mechanisms we describe. Thiazolidinediones (glitazones) are synthetic PPARγ ligands. Epidemiological studies, although inconclusive, [16] have raised concerns about the increased risk of malignancies in type 2 diabetes patients associated with the use of antidiabetic medications. Several studies in ZDF rats, using rosiglitazone as a preventive diabetes treatment (early administration) or a curative one (starting administration when diabetes is well established), indicate, in this animal model, that rosiglitazone has a protective effect on pancreatic β-cell and preserve its secretory function.

These studies are described and discussed, as well as their practical implications.

Tags: , ,