[ Diabetes Type 1 ]

Factors Predicting the Age When Type 2 Diabetes Is Diagnosed in Hong Kong Chinese Subjects

3100 hospitalized type 2 diabetic patients in Peking University People’s Hospital were included in this retrospective study. Tests for seasonal variation in monthly counts aggregated over the 20 yr period were performed. Older age or age at diagnosis and longer diabetes duration proportionally increased the risk of macrovascular events and death, with the greatest risks observed in the oldest age groups with the longest duration of diabetes. Analyses stratified by HLA-risk status found that children with a high risk HLA genotype had an earlier age at diagnosis if they were introduced to fruit juice in the first year of life (mean age of diagnosis=9.3 ± 0.1, 9.1 ± 0.1 and 9.6 ± 0.2 for introduction at ≤ 6 months, between 7 and 11 months, and ≤12 months, respectively; p=0.04). The incidence of AA in rheumatoid arthritis and other chronic arthritides has decreased as a result of the use of more effective anti-inflammatory and immunosuppressive therapies. This real world data shows that the time to insulin therapy has increased in type 2 diabetes patients from 2005 to 2010 (Germany, UK). Favorable cost-effectiveness was robust in sensitivity analysis.

“In the western world it usually appears when BMI is higher, perhaps around 27 to 30. The authors also identified 9,294 patients with diabetes at least three years prior to the index date (the date of ALS diagnosis or the same date for the matched controls), 55 of whom were subsequently diagnosed with ALS. Predictors for younger age at diagnosis in the female patients were higher HbA1c, WHR, and sBP and a paternal as well as maternal history of diabetes. In this study, we used data for adults who self-identified as Chinese, Filipino, South Asian, Japanese, Korean, or Vietnamese and compared them with data for adults who self-identified as non-Hispanic white, reporting diagnosis of type 2 diabetes. We recommend that steps to reduce health disparities between the poorest Appalachian counties and non-Appalachian counties be considered. The results also suggest an onset and progression pattern of the disease that is compatible with the phenomenon of anticipation. This may help explain why women with diabetes have an increased risk of developing cardiovascular disease after the diagnosis of diabetes, compared to men.

Classically, type 2 diabetes develops predominantly in older populations. People who develop diabetes at younger ages can spend more time with undiagnosed, and therefore untreated, diabetes. Early onset of type 2 diabetes appears to be heterogeneous in etiologies. Thus, the risk of dementia also goes down. In Hong Kong Chinese, MODY, typical type 1 diabetes, and atypical autoimmune diabetes do occur, but they only account for a small proportion of the overall type 2 diabetic population (2–4). Given the lifetime nature of diabetes, this decline is most likely attributed to mortality. One possible reason for low utilization within the first 6 months after diagnosis could be that wait times for receiving diabetes self-management education services exceeded 6 months.

One in five American children who has been diagnosed with ADHD is not receiving medicine or mental health counseling for their disorder. Patterns of onset age among successive generations in families segregating type 2 diabetes were also examined. Approval for the study was obtained from the Clinical Research Ethics Committee, the Chinese University of Hong Kong. Informed consent was obtained from each of the participants. 2011. The hospital is a regional teaching hospital with a catchment population of ∼1 million with typical demographic and social class distributions. Our findings should be interpreted in light of the strengths and limitations of our study.

Overall, 32% had high risk or susceptible HLA genotypes. Heart and kidney transplantation may be considered. Patients involved in the study were recruited from our diabetes registry (5). Type 2 diabetes was diagnosed according to the 1985 World Health Organization criteria (9). For the study, 3,414 patients who attended our clinic between 1995 and 1999 were consecutively selected from the diabetes database. All the patients reported the diabetes status of both of their parents as well as their children if they had any. Patients who were diagnosed for 3 years or less by the time of their registration and had already been treated with insulin were not included.

These factors could explain the earlier age at diagnosis noted in our study. Early- and late-onset were hereby defined as diagnosis at ≤35 and >35 years of age, respectively. Moreover, we invited the family members of 21 early-onset and 7 late-onset patients to undergo screening for diabetes using a 75-g oral glucose tolerance test following the previously described procedure (5,9). The overall ascertainment rate among the parents and siblings of the index patients was 85%. All the family members who were reported to have diabetes by the index patients were confirmed with type 2 diabetes in the ascertainment. [19], who found no significant difference among racial and ethnic groups in a 1999-2000 national sample. The seven late-onset patients were randomly selected from the overall late-onset patients who reported at least an affected parent and at least an affected child.

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