[ Diabetes Type 2 ]

Exercise-induced myokines in health and metabolic diseases

A 48-year-old man with a 14-year history of type 2 diabetes with proliferative diabetic retinopathy and distal symmetrical diabetic polyneuropathy visited our hospital. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. One of the significant outcomes of this state is accelerated protein degradation and muscle wasting. DOR has been described as a protein with two different functions, i.e., a nuclear coactivator and an autophagy regulator (Baumgartner et. Animal model of diabetic muscle atrophy was developed by high fat diet (HFD) feeding plus streptozotocin (STZ) injection. As a result, the body cannot produce enough insulin to control the level of glucose in the blood. Those studies set the stage for testing whether ursolic acid and tomatidine might be effective in blocking the largest cause of muscle weakness and atrophy: aging.

Some of these modifications of FOXO factors have been reported to regulate its activity and subcellular location in skeletal muscle [21–25]. Numerous common diseases are associated with muscle weakness and early fatigue development. We propose that dyslipidaemia may be a mechanism for the activation of inflammatory/stress-activated signalling pathways in obesity and type II diabetes, which will lead to apoptosis and atrophy in skeletal muscle. Skeletal muscle expresses and releases myokines into the circulation. A buildup of damaged mitochondria ultimately affects the ability of muscles and nerves to function properly. However, exercise-induced myokines may balance and counteract the effect of adipokines. In response to muscle contraction following exercise, muscle fibers express myokines such as irisin, IL-15, LIF, BDNF, FGF-21, and SPARC, which subsequently exert their effects locally within the muscle or their target organs.

We also know that ultra-rapid weight loss leads to disproportionate muscle loss, which in turn may help to explain why folks who lose weight extremely rapidly, when they inevitably head back to their old lifestyles, gain back more weight than they lost.

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