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Evaluation of aspirin use in patients with diabetes receiving care in community health. – PubMed

Angiolillo DJ, Shoemaker SB, Desai B, et al. We investigated whether long-term low-dose aspirin affects renal dysfunction in patients with diabetes. The present study was designed to determine whether exposure to anti-IFRx is associated with weight loss in T2DM patients. Ten days after the induction of the ulcers, the healing rate and the gastric blood flow (GBF) were measured by planimetry and hydrogen (H(2))-gas clearance method, respectively and the plasma cytokine such as IL-1beta, TNF-alpha and IL-10 were determined. Analyses included χ(2), κ scores, and logistic regressions. In the entire cohort, there was increased risk of hemorrhagic stroke and GI bleeding in the aspirin users. The primary outcomes were rates of appropriate aspirin use and documentation of aspirin therapy in the EHR.

Diabetes mellitus — The most important risk factor for death and myocardial infarction in unstable CAD even after consideration of the extent of coronary lesions and beneficial effects of revascularization. In a population-based cohort, aspirin use was significantly associated with an increased risk of major gastrointestinal or cerebral bleeding episodes. Also, in view of the potential dose-dependent adverse effects of aspirin, with no achievement of further benefit by high dose in this study, it is strongly recommended to use low-dose aspirin as a safe and effective medication for diabetes. Alternatively, 96.7% of patients with aspirin use documented in their EHR were indicated for aspirin therapy compared with only 60.8% of patients who did not have aspirin use documented in the EHR but had an indication (P = 0.0002). However, since diabetes is now considered a CVD equivalent, it is imperative that clinicians include counseling about aspirin therapy as a care priority for all their diabetic patients, as this simple intervention may prevent many cardiovascular events and deaths.

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