[ Diabetes Solutions ]

European researchers developing organoids to spare Type 1 diabetics from lifelong insulin therapy

Diabetes is one of the most common chronic diseases among women of reproductive age, observed in about 10% of pregnancies in the US and approximately 0.2–0.5% of these are in women with type 1 diabetes (T1D). A subgroup analysis may or may not contribute to this bias. Although there is one published 104 week study reporting some safety data, there are no published studies comparing insulin degludec with NPH (isophane) insulin and none that measure patient-oriented efficacy outcomes. This successful post-transplant outcome confirms the initial results achieved by the Diabetes Research Institute in August of 2015. Professor Tim Jones from the University of Western Australia and Associate Professor David O’Neal from the University of Melbourne are evaluating the use of closed-loop devices in real-life for people with type 1 diabetes,  to see if they safely and effectively improve blood glucose control and quality of life. Of the 197 who agreed to participate, 187 could be followed for 6 to 36 months. However, glycemic control was achieved in mice through daily administration of 0.25 U insulin through osmotic pumps.

Our results suggest that it is necessary to improve diabetes management and optimize insulin therapeutic regimens in patients with T1D in Brazil to achieve HbA1c levels within the established targets. A hypo can be dangerous if not treated immediately and because they often go undetected, night-time hypos can be of particular concern to patients and to parents of children living with diabetes. The next step after developing the organoids is to conduct the first clinical studies on transplantation of the organoids. Although transplanting a functional pancreas could cure a Type 1 diabetic, there are insufficient donor organ available. What researchers would do is grow intact cells that produce insulin from donor organs and then transplant the organoid into a patient’s pancreas. Dr Francisco Pampaloni, from the Buchmann Institute for Molecular Life Sciences at the Goethe University, says the method has been proven to work in mice. The omentum is a highly vascularized tissue covering abdominal organs.

“It’s almost the rule that if you live long enough on insulin therapy, you’ll have heart disease” due to insulin’s effects on cholesterol and fatty acid synthesis, he said. Stelzer developed a light microscopy method to follow the growth of biological objects cell for cell in three dimension. Since the light sheet fluorescence microscopy (LSFM) have an important role in the study, the project was calls LSFM4Life. The group is also tasked with developing quality assurance protocols in accordance with good manufacturing practices for pharmaceuticals. Arch Inter Med.

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