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Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. – PubMed

Type 2 diabetes is one of the most common diseases with devastating complications. Metacarpal cortical thickness in 87% of these diabetics was below the mean for their respective ages, while 16% had a cortical thickness value greater than 2 SDS below the mean. He shares some thoughts on how to handle necessary conversations with people you’d rather choke than talk to… The purpose of this review was to evaluate published research on vitamin D in diabetic cardiomyopathy by searching PubMed databases. d-limonene was administered orally at doses of 50, 100 and 200 mg/kg body weight and glibenclamide at a dose of 600 μg/kg body weight daily for 45 days. The binding of 1,25(OH)2D3 to its nuclear vitamin D receptor (VDR) leads to VDR activation and heterodimerization with the retinoid X receptor (RXR) and other cofactors, to form the VDR–RXR complex, which binds to the vitamin D response element of target genes to regulate gene transcription. Alpha-glucosidase did not show significant changes in either tissues.

Statistical analyses were performed using the random effects model and the results expressed as relative risk (RR) for dichotomous outcomes with 95% confidence intervals (CI). In both type I and type II diabetic mellitus, diabetic nephropathy is the most common renal complication that often leads to end-stage kidney disease with its attendant renal failure and high mortality.1 Diabetic nephropathy is a long-term complication, characterized initially by glomerular and tubuloepithelial hypertrophy, and thickening of glomerular and tubular basement membranes, followed by hyperfiltration, albuminuria, glomerulosclerosis, and tubulointerstitial fibrosis, leading eventually to end-stage kidney disease.2 The pathogenesis of diabetic nephropathy is complex and involves direct actions of extracellular glucose on glomerular, tubular, vascular, and interstitial cells. Active vitamin D3 and lentivirus-mediated TGF-β1 interference could effectively reduce the renal fibrosis and protect the renal function in diabetic nephropathy rat models, which makes a promising therapeutic strategy for the disease.

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