OBJECTIVE—The aims of this study were to determine the incidence of diabetes among HIV-infected patients in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) cohort, to identify demographic, HIV-related, and combination antiretroviral therapy (cART)-related factors associated with the onset of diabetes, and to identify possible mechanisms for any relationships found. Methods Relevant case–control and cohort studies published between 1966 and January 2010 were searched in PubMed and EMBASE using the keywords: diabetes vs educational level, occupation or income. By 2014, that number had risen to 422 million — 8.5 per cent of adults — reflecting a global increase in risk factors such as being overweight or obese. Material and Method: The Romanian Society of Diabetes, Nutrition and Metabolic Diseases (RSDNMD) asked the representatives in charge with DM in each county about the total number of subjects registered with DM, the number of subjects with newly diagnosed DM in 2011 and their treatment (insulin or oral drugs). Significant variables associated with the development of diabetes included triglycerides, obesity, fasting plasma glucose, insulin, and degree of American Indian blood among participants with NGT at baseline. The incidence of type 1 diabetes remained relatively constant throughout the study period; however, the incidence of type 2 diabetes increased from 2.60 (2.47–2.74)/1000 person-years in 1996 to 4.31 (4.21–4.42)/1000 person-years in 2005. Rates were also calculated among obese, overweight, and normal weight individuals.
Mortality data are however difficult to interpret, and by relying on hospital documents and death certificates considerably higher incidence rates have been presented than would have been the case had the incidence estimations been based on death certificates alone.