[ Diabetes Solutions ]

Drug combination could help reduce risk of death in type 2 diabetes

This study aims to investigate the distribution of underlying-causes-of-death (UCOD) among deceased patients with type 2 diabetes mellitus (DM) in Taiwan and assess the influence of socio-demographic characteristics on mortality in type 2 DM patients. A recent meta-analysis set out to determine the relative risks (RR) of mortality among patients with type 2 diabetes. The daily pill for Type 2 diabetes reduced deaths from heart complications by 38 percent, deaths from any cause by 32 percent and hospitalizations due to chronic heart failure by 35 percent, according to the study. Predictors of mortality were assessed by Kaplan-Meier survival curves and by uni- and multivariate Cox survival analyses. The simulated incidence of all-cause mortality was 16.4% with a delay of three years and 18.2% with a delay of six years, compared to 14.6% for screening and treatment. Dr Eszter Vamos , lead author of the study from the School of Public Health at Imperial, said: “Most flu deaths every year occur in people with pre-existing health conditions such as type 2 diabetes. And, she added that more studies are necessary to figure out metformin’s possible role in decreasing the risk of dying from cancer.

We have generated exciting results that suggest Bim deficiency protects leptin receptor mutant Leprdb/db mice from development of fasting hyperglycaemia and increases beta cell mass. The primary outcome was a composite of death from cardiovascular causes, non-fatal myocardial infarction, or nonfatal stroke. In analyses of death from cardiovascular causes, which was the principal component of the primary outcome affected by the intervention, there was no evidence of heterogeneity. We found that there was a considerable reduction in deaths and heart problems when this cheap and common drug was used in conjunction with insulin. The study team reviewed data from nearly 146,000 postmenopausal women. The paper Association between insulin monotherapy versus insulin plus metformin and the risk of all-cause mortality and other serious outcomes: a retrospective cohort study was published in the journal PLOS ONE. Thus, smoking is expected to augment an already high mortality among diabetes patients.

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