[ Nutrition ]

Direct measurement of erythrocyte deformability in diabetes mellitus with a transparent microchannel capillary model and


The diagnostic sensitivity and specificity for diabetes of serum fructosamine levels and fasting venous blood glucose concentrations were compared in 613 subjects during a diabetes community screening programme of 1049 adult Muslim Asians in Dar es Salaam, Tanzania. A hybrid algorithm for multivariate calibration is proposed to improve the prediction performance of classification of diabetes and measurement of blood glucose concentration by near infrared (NIR) spectroscopy noninvasively. Although microalbuminuria has been shown to be increased in those with IGT compared with control subjects (2), the incidence of retinopathy (IGT 6.7% vs. An ancillary meta-analysis was performed. The waist circumference locations that were measured in this study included the midpoint between the lowest rib and the iliac crest, as defined by the World Health Organization; the umbilical level, as defined by the Japanese metabolic syndrome guidelines; and immediately above the iliac crest, as defined by the National Cholesterol Education Program’s Adult Treatment Panel III (NCEP-ATPIII) guidelines. The DDS17 had a Cronbach’s alpha of 0.92; subscale alphas were 0.83-0.89. Nuclear imaging of the animals that received an injection of the radioactive probe showed major difference in signal intensity between normal and diabetic pancreases.

The measurement of HbA1c (a so-called Amadori product, actually an intermediate product of the Maillard reaction) as a parameter that mirrors the quality of glycemic control within the previous 8 to 12 weeks has markedly contributed to the guidance of diabetes therapy, but also to our understanding of the development of diabetes complications.10 The results of Diabetes Control and Complication Trial—Epidemiology of Diabetes Interventions and Complications have strengthened the “glycemic memory” concept, postulating that metabolic control over several years predicts the development of diabetic complications.11 The fact that glycated proteins form under hyperglycemic conditions, accumulate within organs that are prone to diabetic complication, and have a very long persistence, suggests AGEs to be ideal candidates for the substrate of the “glycemic memory.”12⇓-14 In other words, by measuring AGEs one can assess the overall hyperglycemic burden of the last years. In order to identify the difference in erythrocyte deformability between control and diabetic erythrocytes, we measured erythrocyte deformability using transparent crystal microchannels and a high-speed video camera system. QoL assessment has the proven potential to identify ways in which treatments can be tailored to reduce the burden of diabetes. By pricking at different depths using a lancing device you can obtain a drop of blood from the side of the fingertip easily and relatively painlessly.

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