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Diabetic Retinopathy Eye disease

Diabetes is very common and uncontrolled blood sugar can have devastating effects on your vision! The blood vessels were created with induced pluripotent stem cells (iPSCs) derived from the mature skin cells of both healthy adults and individuals with type 1 diabetes. Dr. Her writing and presentations have focused on both scientific and patient audiences. It has found that out of 1,181 diabetic patient, 206 died and 216… Your heart and blood vessels work together to bring oxygen to all parts of your body, including your brain, heart, legs, and lungs. THEY STUDIED MICE THAT WERE GENETICALLY ENGINEERED SO THAT THEY COULDN’T MAKE FATTY ACID SYNTHASE IN THEIR ENDOTHELIAL CELLS THAT LINE BLOOD VESSELS, ACCORDING TO SENIOR INVESTIGATOR CLAY SEMENKOVICH.

Gasser Professor of Medicine. Aneurysms are dangerous because they may burst, spilling blood into the area surrounding the blood vessel. Comparing FASTie mice to normal animals, as well as to mice with diabetes, Wei and Semenkovich determined that mice without FAS, and with low levels of FAS, could not make the substance that anchors nitric oxide synthase to the endothelial cells in blood vessels. Her current research therefore aims to develop microRNAs delivered in vesicles as novel therapies for heart and blood vessel disease. Semenkovich, MD, the Irene E. Sam Gandy, associate director of the Mount Sinai Alzheimer’s Disease Research Center in New York City. If intrinsic factor can’t attach to the gut membrane – the vitamin B12 is not absorbed.

A comprehensive eye exam involves a visual acuity test to measure vision at various distances, and a dilated eye exam to examine the structures of the eye for any signs of disease. Blurry vision may occur as an indication of swelling in the retina. The primary risk factor for diabetic retinopathy is high blood glucose levels over time in individuals with uncontrolled diabetes. Many people with diabetes have mild NPDR, which usually does not affect their vision. For example, if leaking blood vessels are detected, they can often be ablated with a laser in clinic and stave off further damage. Vitreous haemorrhage: delicate new blood vessels bleed into the vitreous (the gel in the centre of the eye) preventing light rays from reaching the retina. If the vitreous haemorrhage is small, you may see a few new, dark floaters.

Some strokes cause no obvious symptoms despite the brain damage. Vitreous haemorrhage alone does not cause permanent vision loss. Sometimes a type of test called nuclear imaging may be used instead. Traction retinal detachment: scar tissue from neovascularization shrinks, causing the retina to wrinkle and pull from its normal position. Macular wrinkling can distort your vision. More severe vision loss can occur if the macula or large areas of the retina are detached. Louis Children’s hospitals, the School of Medicine is linked to BJC HealthCare.

In this condition, the new blood vessels may block the normal flow of fluid out of the eye. Pressure builds up in the eye, a particularly severe condition that causes damage to the optic nerve. Blood sugar levels – Controlling your blood sugar is the key risk factor that you can affect. Lower blood sugar levels can delay the onset and slow the progression of diabetic retinopathy. Blood pressure – A major clinical trial demonstrated that effectively controlling blood pressure reduces the risk of retinopathy progression and visual acuity deterioration. High blood pressure damages your blood vessels raising the chances for eye problems. Target blood pressure for most people with diabetes is less than 130/80 mmHg.

Duration of diabetes – The risk of developing diabetic retinopathy or having your disease progress increases over time. After 15 years 80% percent of Type I patients will have diabetic retinopathy. After 19 years up to 84% of patients with Type II diabetes will have diabetic retinopathy. Blood lipid levels (cholesterol and triglycerides) – Elevated blood lipid levels can lead to greater accumulation of exudates, protein deposits that leak into the retina. This condition is associated with a higher risk of moderate visual loss. Pregnancy – Being pregnant can cause changes to your eyes. If you have diabetes and become pregnant your risk for diabetic retinopathy increases.

If you already have diabetic retinopathy it may progress. However, some studies have suggested that with treatment these changes are reversed after you give birth and that there is no increase in long term progression of the disease. The best treatment for diabetic retinopathy is to prevent it. Strict control of your blood sugar will significantly reduce the long term risk of vision loss. Treatment usually will note cure diabetic retinopathy nor does it usually restore normal vision, but it may slow the progression of vision loss. Without treatment, diabetic retinopathy progresses steadily from minimal to severe stages. The laser is a very bright, finely focused light.

Laser shrinks abnormal new vessels and reduces macular swelling. Treatment is often recommended for people with macular oedema, proliferative diabetic retinopathy (PDR) and neovascular Glaucoma. With laser treatment for macular oedema, tiny laser burns are applied near the macula to reduce fluid leakage. The main goal of treatment is to prevent further loss of vision by reducing the swelling of the macula. It is uncommon for people who have blurred vision from macular oedema to recover normal vision, although some may experience partial improvement. In PDR, the laser is applied to all parts of the retina except the macula (called PRP or pan retinal photocoagulation). This treatment causes abnormal new vessels to shrink and often prevents them from growing in the future.

It also decreases the chance that vitreous bleeding or retinal distortion will occur. Pan retinal laser has proven to be very effective for preventing severe vision loss from vitreous haemorrhage and traction retinal detachment. In some cases, medication may be used to help treat diabetic retinopathy. Sometimes a steroid medication is used. In other cases you may be given an anti-VEGF medication. This medication works by blocking a substance known as vascular endothelial growth factor or VEGF. This substance contributes to abnormal blood vessel growth in the eye which can affect your vision.

An anti-VEGF drug can help reduce the growth of these abnormal blood vessels. After your pupil is dilated and your eye is numbed with anaesthesia, the medication is injected into the vitreous, or jelly like substance in the back chamber of the eye. The medication reduces the swelling, leakage, and growth of unwanted blood vessel growth in the retina and may improve how well you see. Vitrectomy often prevents further vitreous haemorrhage by removing the abnormal vessels that caused the bleeding. Removal of the scar tissue helps the retina return to its normal location. Laser surgery may be performed during vitrectomy surgery. To help the retina heal in place, your retinal specialist may place a gas or oil bubble in the vitreous space.

You may be told to keep your head in certain positions while the bubble helps to heal the retina. It is important to follow your ophthalmologists instructions so your eye will heal properly.

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