[ Diabetes Type 2 ]

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves’ Disease and to Type 1 Diabetes Mellitus: The


OBJECTIVE: To assess the prevalence of Graves’ disease in patients with type 1 diabetes mellitus all coming from a defined geographical area (western Sicily-Italy) and to investigate the clinical features of these subjects. Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves’ Disease (GD), systemic lupus erythematosus (SLE), Wegener’s granulomatosis (WG) and type 1 diabetes mellitus (T1D). 255 patients with Graves disease (216 females and 39 males) and 69 patients (63 females and 6 males) mean age 53.6 +/- 13.7 years were examined. This process is referred to as thyroid eye disease, thyroid-associated ophthalmopathy or Graves’ orbitopathy. This has effects throughout the body. They do not damage the thyroid gland and may be used for short- or long-term treatment. Our results suggest that gammadelta T cells (gammadelta TCR+CD8- subset) could also play an important role in the development of Graves’ disease and that their levels are modulated by thyreostatic treatment.

Many are overweight, find it difficult to lose weight, and suffer with fatigue, depression and anxiety. A lot of the symptoms for hypothyroidism can be seen as the opposite of those of hyperthyroidism. No previous case has ever been reported in the English literature. Partial Thyroid Lobectomy This operation is not performed very often because there are not many conditions which will allow this limited approach.

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