[ Diabetes Solutions ]

Could Metformin Manage Gestational Diabetes Mellitus instead of Insulin?

Women who develop gestational diabetes mellitus (GDM) have severe insulin resistance and markedly increased risk to develop subsequent type 2 diabetes. A total of 21 women with normal glucose tolerance and 21 women with GDM were evaluated at 24-36 weeks’ gestation. Here, we investigated whether mild gestational diabetes mellitus (GDM) followed or not by maternal insulin replacement affects the ventral prostate (VP) structure and function in male offspring at puberty and adulthood. She experienced dyspnea, cough, urticaria and itching sensation at the sites of insulin injection immediately after insulin administration. There are no reports of the use of insulin glulisine in pregnancy and so its use cannot be recommended. Among Caucasian subjects, a similar relationship between the INSR allele 1 (P = 0.007) and INSR allele 1-BMI interactions (P = 0.011) on GDM risk were observed. 36.2 ± 13.0 ng/ml), when osteocalcin was found to be increased compared with the level in the pregnant state in all women (+145 ± 102% in GDM vs.


However, in the case we report, the lack of allergy during a few weeks allowed the birth of a normal infant. Diabetes mellitus (DM) is a metabolic disorder of multiple etiology characterized by, chronic hyperglycemia with disturbance of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both [1]. Appropriate lifestyle measures can help delay your need for extra insulin. Une allergie à l’insuline a été suspectée devant l’apparition de lésions cutanées aux sites d’injection de l’insuline et une diminution de l’efficacité de l’insuline. A second oral glucose tolerance test should therefore be performed at the standard 26–28 weeks of gestation even if an earlier test was normal. Results. No significant difference in controlling high blood sugar in GDM with the use of metformin or insulin (, 0.15).

Maternal complications in both groups had no significant difference and fetal outcomes were as well similar except the fact that the hypoglycemia occurred more in insulin group with value 0.01. Conclusion. Glycaemic control in GDM can be achieved by using metformin orally without increasing risk of maternal hypoglycemia with satisfying neonatal outcome. Gestational diabetes mellitus (GDM) is a condition with any level of glucose intolerance which began or was detected for first time during pregnancy despite type of management; it may also relate to situations that continue after pregnancy. It affects approximately 7% of pregnancies with an incidence of more than 200,000 cases per year [1]. Older and more obese pregnant women have the highest incidence of GDM. Moderate weight loss and regular exercise have also been found to increase osteocalcin concentrations, partly by direct effects of exercise on bone remodeling and partly by a reduction in visceral fat (9).

A 31-year-old pregnant woman (weight 92 kg, BMI 35) was diagnosed as having a gestational diabetes at 25 weeks of amenorrhoea. The excretion of metformin is influenced significantly by a variant allele (SLC22A2) and could result in treatment failure or toxicity in carriers of this allele [10], hence the need for studies in our population. Extreme mother-to-fetus glucose transmit is an augmented hazard for congenital defects, neonatal death, and still birth. The hyperglycemic environment intrauterine influences children later in life [5]. Occasionally, women may have elevated postprandial blood glucose with normal fasting levels. Neonatal hypoglycemia directly after birth is one of the most risky complications, putting neonate in danger [6].

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