Rae Uddin has worked as a freelance writer and editor since 2004. They investigated the effects of cinnamon supplementation on insulin sensitivity, glucose tolerance and blood cholesterol profile in patients with type 2 diabetes. The rats were divided into saline and cinnamon extract (30 and 300 mg/kg BW-doses: C30 and C300) oral administration groups. If you have a team, register online before the registration deadline (ima.rsp.washington.edu). The other 90 per cent of people have type 2 diabetes, where the body either fails to produce enough insulin or is resistant to it. Cinnamon intake, either as whole cinnamon or as cinnamon extract, results in a statistically significant lowering in FBG (-0.49±0.2 mmol/L; n=8, P=.025) and intake of cinnamon extract only also lowered FBG (-0.48 mmol/L±0.17; n=5, P=.008). This is comparable to the action of commonly used thiazolinediones, which are PPAR agonists.
Additional clinical research in humans is needed, however, to substantiate these purported health effects of cinnamon. Due to the conflicting results, we simply cannot draw a conclusion about any possible benefits of cinnamon at this point. While some studies have showed no beneficial effect, others have indicated improvements in cholesterol levels, systolic blood pressure, insulin sensitivity and postprandial glucose levels with cinnamon. What is part of the game is the pure satisfaction of participation (fun, fitness, friendships, stress release, etc…). Research from the University of Washington even suggests that high blood sugars are strongly related to increased risk of Alzheimer’s. Apart from further characterization of genetic and epigenetic changes in model systems, systematic large-scale clinical trials are required. In this study, we discuss the mechanisms of action of cinnamon in the context of T2D and we highlight some of the associated controversies.